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Uristatin Immunoassay Usage in Glomerular Nephritis Assessment

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Inflammatory Pathways in Diabetes

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

A novel immunoassays for Uristatin (Uri) was used for testing in patients glomerular nephritis (GN) by using of an extensive clinical data and urine sample bank from previous studies (n = 6292 patients). Proteinuira or hematuria was found in 1407 of 6292 patients and used an indicator for potential cases needing glomerular nephritis follow up. Of these, 351 patients had asymptomatic GN without infection or Uri. The remaining 1194 patients had potential infections based on symptoms of urinary tract infection, systemic infections, and/or a positive Uri value >12 mg/L. Urine culture and CBC were used to characterize 419 patients as actually having infections. Those remaining were sorted according to Uri value as 198 cases of symptomatic GN with anti-inflammatory stress (Uri >12 mg/L) and 533 cases without this stress (Uri <12 mg/L). The Uri method allowed sorting atypical anti-inflammatory stress patient in glomerular nephritis.

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Acknowledgements

We would like to thank Ronald Sommer, Dr Hai-Hang Kuo, and Dr. Manju Basu for their many hours of effort in performing uristatin ELISA testing. We would also like to thank, Dr. Roland Valdes, Mr. Glen Renfrew, Dr. Darryl L. Gopual, Dr. John Lott and Dr. Chris Price for their helpful guidance to build this patient sample bank, with helpful advice over many years and the various studies.

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Authors and Affiliations

  1. Department of Pathology, University of Louisville, School of Medicine, 511 S. Floyd Street (Room 227), Louisville, KY, 40202, USA

    Saeed A. Jortani

  2. Department of Pathology, University of Louisville, School of Medicine, Louisville, KY, 40202, USA

    Michael Pugia

  3. Strategic Innovation, Siemens Healthcare Diagnostics, 3400 Middlebury Street, Elkhart, IN, 46530, USA

    Michael Pugia

Authors
  1. Saeed A. Jortani
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  2. Michael Pugia
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Correspondence to Michael Pugia .

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Editors and Affiliations

  1. Strategic Innovation, Siemens Healthcare Diagnostics, Elkhart, Indiana, USA

    Michael Pugia

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Jortani, S.A., Pugia, M. (2015). Uristatin Immunoassay Usage in Glomerular Nephritis Assessment. In: Pugia, M. (eds) Inflammatory Pathways in Diabetes. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-21927-1_7

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