Abstract
Over the years several in-vivo injury models have been developed to study the effects of blast injuries to experimental animals, in order to identify the injury mechanisms involved in the pathobiology of blast injury. This review provides an overview of the most commonly used blast injury models and the local and systemic changes induced in a wide range of tissues following blast.
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Nguyen TTN, Wilgeroth JM, Proud WG. Controlling blast wave generation in a shock tube for biological applications. In: 18th APS-SCCM and 24th AIRAPT, Seattle/Washington, DC.
Cernak I, et al. The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiol Dis. 2011;41(2):538–51.
Long JB, et al. Blast overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma. 2009;26(6):827–40.
Goldstein LE, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4:134ra60.
Svetlov S, et al. Morphological and biochemical signatures of brain injury following head-directed controlled blast overpressure impact. J Neurotrauma. 2009;26(8):A75.
Chavko M, Prusaczyk WK, McCarron RM. Lung injury and recovery after exposure to blast overpressure. J Trauma. 2006;61(4):933–42.
Risling M, et al. Experimental studies on mechanisms of blast induced brain injuries. J Neurotrauma. 2009;26(8):A74.
Risling M, Davidsson J. Experimental animal models for studies on the mechanisms of blast-induced neurotrauma. Front Neurol. 2012;3(30).
Chandra N, et al. Evolution of blast wave profiles in simulated air blasts: experiment and computational modeling. Shock Waves. 2012;22(5):403–15.
Skotak M, et al. Rat injury model under controlled field-relevant primary blast conditions: acute response to a wide range of peak overpressures 7. J Neurotrauma. 2013;30(13):1147–60.
Mohan K, et al. Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury. Invest Ophthalmol Vis Sci. 2013;54(5):3440–50.
Cernak I. Animal models of head trauma. NeuroRx J Am Soc Exp Neurother. 2005;2(3):410–22.
Clemedson CJ, Jonsson A. Effects of frequency content in complex air shock-waves on lung injuries in rabbits. Aviat Space Environ Med. 1976;47(11):1143–52.
Clemedson CJ. Shock wave transmission to the central nervous system. Acta Physiol Scand. 1956;37(2–3):204–14.
Bauman RA, et al. An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma. 2009;26(6):841–60.
Risling M, et al. Mechanisms of blast induced brain injuries, experimental studies in rats. Neuroimage. 2011;54:S89–97.
Saljo A, et al. Mechanisms and pathophysiology of the low-level blast brain injury in animal models. Neuroimage. 2011;54:S83–8.
Bass CR, et al. Brain injuries from blast. Ann Biomed Eng. 2012;40(1):185–202.
Cheng JM, et al. Development of a rat model for studying blast-induced traumatic brain injury. J Neurol Sci. 2010;294(1–2):23–8.
Rubovitch V, et al. A mouse model of blast-induced mild traumatic brain injury. Exp Neurol. 2011;232(2):280–9.
Kuehn R, et al. Rodent model of direct cranial blast injury. J Neurotrauma. 2011;28(10):2155–69.
Ogura M, et al. In vivo targeted gene transfer in skin by the use of laser-induced stress waves. Lasers Surg Med. 2004;34(3):242–8.
Hatano B, et al. Traumatic brain injury caused by laser-induced shock wave in rats: a novel laboratory model for studying blast-induced traumatic brain injury. Proc SPIE. 2011;7897:78971V.
Satoh Y, et al. Pulmonary blast injury in mice: a novel model for studying blast injury in the laboratory using laser-induced stress waves. Lasers Surg Med. 2010;42(4):313–8.
Panzer MB, Wood GW, Bass CR. Scaling in neurotrauma: how do we apply animal experiments to people? Exp Neurol. 2014;261:120–6.
DePalma RG, et al. Current concepts: blast injuries. N Engl J Med. 2005;352(13):1335–42.
Crockard HA, et al. An experimental cerebral missile injury model in primates. J Neurosurg. 1977;46:776–83.
Finnie JW. Pathology of experimental traumatic craniocerebral missile injury. J Comp Pathol. 1993;108:93–101.
Suneson A, Hansson HA, Seeman T. Peripheral high-energy missile hits cause pressure changes and damage to the nervous-system – experimental studies on pigs. J Trauma. 1987;27(7):782–9.
Carey ME, et al. Experimental missile wound to the brain. J Neurosurg. 1989;71(5):754–64.
Tan YH, et al. A gross and microscopic study of cerebral injuries accompanying maxillofacial high-velocity projectile wounding in dogs. J Oral Maxillofac Surg. 1998;56(3):345–8.
Plantman S, Davidsson J, Risling M. Characterization of a novel model for penetrating brain injury. J Neurotrauma. 2009;26(8):A86.
Proctor JL, et al. Rat model of brain injury caused by under-vehicle blast-induced hyperacceleration. J Trauma Acute Care Surg. 2014;77:S83–7.
Elder GA, et al. Blast-induced mild traumatic brain injury. Psychiatr Clin North Am. 2010;33(4):757–81.
Courtney MW, Courtney AC. Working toward exposure thresholds for blast-induced traumatic brain injury: thoracic and acceleration mechanisms. Neuroimage. 2011;54:S55–61.
Phillips YY, Richmond DR. Primary blast injury and basic research: a brief history. In: Textbook of military medicine, Part I, Conventional warfare: ballistic, blast and burn injuries. Washington, DC: Office of the Surgeon General of the US Army; 1990.
Andersen P, Loken S. Lung damage and lethality by underwater detonations. Acta Physiol Scand. 1968;72(1–2):6–14.
Tannous O, et al. Heterotopic ossification after extremity blast amputation in a Sprague–Dawley rat animal model. J Orthop Trauma. 2011;25(8):506–10.
de Lanerolle NC, et al. Characteristics of an explosive blast-induced brain injury in an experimental model. J Neuropathol Exp Neurol. 2011;70(11):1046–57.
Warden D. Military TBI during the Iraq and Afghanistan wars. J Head Trauma Rehabil. 2006;21(5):398–402.
Park E, et al. Electrophysiological white matter dysfunction and association with neurobehavioral deficits following low-level primary blast trauma. Neurobiol Dis. 2013;52:150–9.
Pun PBL, et al. Low level primary blast injury in rodent brain. Front Neurol. 2011;2:1–15.
Park E, et al. A model of low-level primary blast brain trauma results in cytoskeletal proteolysis and chronic functional impairment in the absence of lung barotrauma. J Neurotrauma. 2011;28(3):343–57.
Gao W, et al. Association between reduced expression of hippocampal glucocorticoid receptors and cognitive dysfunction in a rat model of traumatic brain injury due to lateral head acceleration. Neurosci Lett. 2013;533:50–4.
Ikonomovic MD, et al. Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol. 2004;190(1):192–203.
DeKosky ST, et al. Association of increased cortical soluble A beta(42) levels with diffuse plaques after severe brain injury in humans. Arch Neurol. 2007;64(4):541–4.
De Gasperi R, et al. Acute blast injury reduces brain abeta in two rodent species. Front Neurol. 2012;3(177):1–17.
Garman RH, et al. Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury. J Neurotrauma. 2011;28(6):947–59.
Lighthall JW. Controlled cortical impact: a new experimental brain injury model. J Neurotrauma. 1988;5(1):1–15.
Hall KD, Lifshitz J. Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses. Brain Res. 2010;1323:161–73.
Singleton RH, et al. Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death. J Neurosci. 2002;22(3):791–802.
Singleton RH, Povlishock JT. Diffuse brain injury-mediated neuronal somatic plasmalemmal wounding: a study of the effects of membrane disruption on neuronal reaction and fate. J Neurotrauma. 2003;20(10):1125.
Chavko M, Prusaczyk WK, McCarron RM. Protection against blast-induced mortality in rats by hemin. J Trauma. 2008;65(5):1140–5.
Koliatsos VE, et al. A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization. J Neuropathol Exp Neurol. 2011;70(5):399–416.
Rafaels K, et al. Brain injury from primary blast. Brain Inj. 2012;26(4–5):745–6.
Cernak I, et al. Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma. 1996;40(3):S100–4.
Bhattacharjee Y. Neuroscience – shell shock revisited: solving the puzzle of blast trauma. Science. 2008;319(5862):406–8.
Ning JL, et al. Lung injury following lower extremity blast trauma in rats. J Trauma Acute Care Surg. 2012;73(6):1537–44.
Ning JL, et al. Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma. Crit Care Med. 2014;42(1):E68–78.
Delius M, et al. Biological effects of shock-waves – lung hemorrhage by shock-waves in dogs – pressure-dependence. Ultrasound Med Biol. 1987;13(2):61–7.
Seitz DH, et al. Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils. Shock. 2008;30(5):537–44.
Sasser SM, et al. Blast lung injury. Prehosp Emerg Care. 2006;10(2):165–72.
Gorbunov NV, et al. Pro-inflammatory alterations and status of blood plasma iron in a model of blast-induced lung trauma. Int J Immunopathol Pharmacol. 2005;18(3):547–56.
Rafaels KA, et al. Pulmonary injury risk assessment for long-duration blasts: a meta-analysis. J Trauma. 2010;69(2):368–74.
Bass CR, Rafaels KA, Salzar RS. Pulmonary injury risk assessment for short-duration blasts. J Trauma. 2008;65(3):604–15.
Chai JK, et al. Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats. Burns. 2013;39(4):745–53.
Chai JK, et al. A novel model of burn-blast combined injury and its phasic changes of blood coagulation in rats. Shock. 2013;40(4):297–302.
Elsayed NM. Toxicology of blast over-pressure. Toxicology. 1997;121(1):1–15.
Alfieri KA, Forsberg JA, Potter BK. Blast injuries and heterotopic ossification. Bone Joint Res. 2012;1(8):174–9.
Salisbury E, et al. Sensory nerve induced inflammation contributes to heterotopic ossification. J Cell Biochem. 2011;112(10):2748–58.
Apel PJ, et al. Effect of selective sensory denervation on fracture-healing an experimental study of rats. J Bone Joint Surg Am. 2009;91A(12):2886–95.
Yano H, et al. Substance-P-induced augmentation of cutaneous vascular-permeability and granulocyte infiltration in mice is mast-cell dependent. J Clin Invest. 1989;84(4):1276–86.
Polfer EM, et al. The development of a rat model to investigate the formation of blast-related post-traumatic heterotopic ossification. Bone Joint J. 2015;97-B(4):572–6.
Qureshi AT, et al. Early characterization of blast-related heterotopic ossification in a rat model. Clin Orthop Relat Res. 2015;473(9):2831–9.
Patterson JH, Hamernik RP. Blast overpressure induced structural and functional changes in the auditory system. Toxicology. 1997;121(1):29–40.
Luo H, et al. Blast-induced tinnitus and spontaneous firing changes in the rat dorsal cochlear nucleus. J Neurosci Res. 2014;92(11):1466–77.
Mao JC, et al. Blast-induced tinnitus and hearing loss in rats: behavioral and imaging assays. J Neurotrauma. 2012;29(2):430–44.
Kurioka T, et al. Characteristics of laser-induced shock wave injury to the inner ear of rats. J Biomed Opt. 2014;19(12):125001.
Newman AJ, et al. Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces. J Neurosci Methods. 2015;242:82–92.
Wu JA, et al. Study of protective effect on rat cochlear spiral ganglion after blast exposure by adenovirus-mediated human beta-nerve growth factor gene. Am J Otolaryngol. 2011;32(1):8–12.
Birch R, et al. Nerve injuries sustained during warfare part II: outcomes. J Bone Joint Surg Br. 2012;94B(4):529–35.
Christensen AM, et al. Primary and secondary skeletal blast trauma. J Forensic Sci. 2012;57(1):6–11.
Claes L, et al. The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model. Acta Orthop. 2011;82(2):223–7.
Birch R, et al. Nerve injuries sustained during warfare part I – epidemiology. J Bone Joint Surg Br. 2012;94B(4):523–8.
Suneson A, Seeman T. Pressure wave injuries to the nervous-system caused by high-energy missile extremity impact.1. Local and distant effects on the peripheral nervous-system – a light and electron-microscopic study on pigs. J Trauma. 1990;30(3):281–94.
Bellander BM, et al. Genetic regulation of microglia activation, complement expression, and neurodegeneration in a rat model of traumatic brain injury. Exp Brain Res. 2010;205(1):103–14.
Panzer MB, Bass CRD. Human results from animal models: scaling laws for blast neurotrauma. J Neurotrauma. 2012;29(10):A151.
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Eftaxiopoulou, T. (2016). In-Vivo Models of Blast Injury. In: Bull, A., Clasper, J., Mahoney, P. (eds) Blast Injury Science and Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-21867-0_13
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DOI: https://doi.org/10.1007/978-3-319-21867-0_13
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