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Organ-on-a-Chip Platforms for Drug Screening and Tissue Engineering

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Biomedical Engineering: Frontier Research and Converging Technologies

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 9))

Abstract

Developments in micro- and nanofluidic technologies have led to new kinds of cell culture and screening systems that are collectively termed organ-on-a-chip systems. Organ-on-a-chip systems are in vitro microfabricated devices that mimic dynamic interactions of in vivo microenvironments. In addition to existing two-dimensional and three-dimensional cell tissues, organ-on-a-chip systems can mimic the biomechanical and biochemical microenvironment of in vivo tissues as well as the interaction effect of the microenvironment on cell and tissue functions. Due to these features, organ-on-a-chip systems have become excellent platforms for drug screening and delivery test and tissue engineering. In this review, specific examples of various types of organ-on-a-chip devices and their applications in tissue engineering and drug delivery test are discussed. The ready feasibility and performance of current state-of-the-art organ-on-a-chip systems, including lung-on-a-chip, heart-on-a-chip, liver-on-a-chip, vessel-on-a-chip, and tumor-on-a-chip are also covered in this chapter. The limitations of conventional systems, basic fabrication process of organ-on-a-chip devices, and future prospective of organ-on-a-chip are discussed.

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Authors and Affiliations

  1. School of Engineering, University of British Columbia, Kelowna, BC, V1V 1V7, Canada

    Zongjie Wang, Roya Samanipour & Keekyoung Kim

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  1. Zongjie Wang
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  2. Roya Samanipour
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  3. Keekyoung Kim
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Correspondence to Keekyoung Kim .

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Editors and Affiliations

  1. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia, USA

    Hanjoong Jo

  2. Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, Alabama, USA

    Ho-Wook Jun

  3. Department of Mechanical Engineering Soft Biomechanics & Biomaterials Lab, Korea Advanced Institute of Science and Technology, Daejeon (KAIST), Korea (Republic of)

    Jennifer Shin

  4. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea (Republic of)

    SangHoon Lee

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Wang, Z., Samanipour, R., Kim, K. (2016). Organ-on-a-Chip Platforms for Drug Screening and Tissue Engineering. In: Jo, H., Jun, HW., Shin, J., Lee, S. (eds) Biomedical Engineering: Frontier Research and Converging Technologies. Biosystems & Biorobotics, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-21813-7_10

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  • DOI: https://doi.org/10.1007/978-3-319-21813-7_10

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