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Nanoparticles for Imaging and Non-viral Gene Therapy

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Biomedical Engineering: Frontier Research and Converging Technologies

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 9))

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Abstract

Gene therapy has not been investigated as much as pharmacotherapy because of immunogenic issues when a virus was used as a gene delivery vector. Despite the challenges, gene therapy still has attractive aspects. It has less side effects and is more target-specific compared to pharmacotherapy, and it also has potential for generic disease treatment or personalized medicine. Therefore, it would be truly beneficial if safe and reliable vectors are used and targeted for area of interest. Interest in multifunctional nanomedicine for diagnostics and therapeutics has been increasing. For this reason, non-viral gene delivery has been studied, combined with molecular imaging to visualize targeting. In this review, complex nanoparticle systems designed for molecular imaging and gene delivery are discussed. There are design criteria which need to be considered for the nanoparticle complex systems. The criteria are as follows: i) the nanoparticle complex should be stable; ii) it should have efficient targeting capability; iii) controlled release of genes should be available; iv) molecular imaging should be possible; and lastly, v) there should be noticeable therapeutic efficacy. Examples on nanoparticle complex which meet these criteria are described in the review.

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Authors and Affiliations

  1. Department of Biomedical, Chemical & Environmental Engineering, University of Cincinnati, Cincinnati, USA

    Yoonjee Park

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  1. Yoonjee Park
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Correspondence to Yoonjee Park .

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Editors and Affiliations

  1. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia, USA

    Hanjoong Jo

  2. Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, Alabama, USA

    Ho-Wook Jun

  3. Department of Mechanical Engineering Soft Biomechanics & Biomaterials Lab, Korea Advanced Institute of Science and Technology, Daejeon (KAIST), Korea (Republic of)

    Jennifer Shin

  4. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea (Republic of)

    SangHoon Lee

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Park, Y. (2016). Nanoparticles for Imaging and Non-viral Gene Therapy. In: Jo, H., Jun, HW., Shin, J., Lee, S. (eds) Biomedical Engineering: Frontier Research and Converging Technologies. Biosystems & Biorobotics, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-21813-7_1

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  • DOI: https://doi.org/10.1007/978-3-319-21813-7_1

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