Abstract
This chapter covers the frozen section evaluation of uterine contents for confirmation of intrauterine pregnancy and gestational trophoblastic disease (GTD). The latter encompasses a spectrum of proliferative disorders of placental trophoblast ranging from nonneoplastic hydatidiform moles (partial and complete mole) to malignant trophoblastic tumors. The most aggressive form of trophoblastic neoplasia, gestational choriocarcinoma, has become uncommon nowadays. Two distinct tumors of the intermediate trophoblast (placental site trophoblastic tumor and epithelioid trophoblastic tumor) are rare but frequently pose a diagnostic challenge when encountered. In addition, two reactive conditions (exaggerated placental site reaction and placental site nodule) are also classified within GTD due to their potential misdiagnosis as neoplastic processes.
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References
Kurman RJ, Carcanglu ML, Herrington CS, Young RH. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2014; 155–67.
Keep D, Zaragoza MV, Hassold T, Redline RW. Very early complete hydatidiform mole. Hum Pathol. 1996;27:708–13.
Buza N, Hui P. Partial hydatidiform mole: histologic parameters in correlation with DNA genotyping. Int J Gynecol Pathol. 2013;32(3):307–15.
Gaber LW, Redline RW, Mostoufi-Zadeh M, Driscoll SG. Invasive partial mole. Am J Clin Pathol. 1986;85(6):722–4.
Ober WB, Edgcomb JH, Price Jr EB. The pathology of choriocarcinoma. Ann N Y Acad Sci. 1971;172:299–426.
Bower M, Brock C, Fisher RA, Newlands ES, Rustin GJ. Gestational choriocarcinoma. Ann Oncol. 1995;6:503–8.
Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE. Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol. 2006;100:511–20.
Fadare O, Parkash V, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: clinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol. 2006;19:75–82.
Shih IM, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol. 2001;20:31–47.
Young RH, Kurman RJ, Scully RE. Placental site nodules and plaques. A clinicopathologic analysis of 20 cases. Am J Surg Pathol. 1990;14:1001–9.
Huettner PC, Gersell DJ. Placental site nodule: a clinicopathologic study of 38 cases. Int J Gynecol Pathol. 1994;13:191–8.
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Hui, P., Buza, N. (2015). Intrauterine Pregnancy and Gestational Trophoblastic Disease. In: Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-21807-6_6
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DOI: https://doi.org/10.1007/978-3-319-21807-6_6
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-21806-9
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