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Uterine Cervix

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Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology

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Abstract

Squamous cell carcinoma is the most common cervical malignancy and is caused by high-risk human papillomavirus (HPV) with viral DNA integration into the host cell genome [1]. Most tumors are conventional squamous cell carcinomas of either keratinizing or nonkeratinizing large cell type. Common histological variants include verrucous, basaloid, papillary, lymphoepitheliomatous, and spindled squamous carcinomas. Invasive adenocarcinoma of the cervix now represents 10–20 % of all cervical cancers. Similar to squamous carcinoma, high-risk HPV, particularly type 18, is the causal agent for most of the cases. The histological spectrum of cervical adenocarcinomas includes usual endocervical adenocarcinoma, endometrioid adenocarcinoma, and gastrointestinal-type mucinous carcinoma and its variants including minimal deviation adenocarcinoma (adenoma malignum), villoglandular adenocarcinoma, adenoid basal carcinoma, adenosquamous carcinoma, serous carcinoma, and clear cell carcinoma. Malignant stromal tumors of the cervix are uncommon. Many reactive, metaplastic, and tumorlike conditions may simulate various malignant processes of the cervix.

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Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Pei Hui & Natalia Buza

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  1. Pei Hui
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  2. Natalia Buza
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Hui, P., Buza, N. (2015). Uterine Cervix. In: Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-21807-6_3

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  • DOI: https://doi.org/10.1007/978-3-319-21807-6_3

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-21806-9

  • Online ISBN: 978-3-319-21807-6

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