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Vulva and Vagina

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Book cover Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology

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Abstract

Tumors of the vulva and vagina share overall histological classifications of neoplastic lesions into squamous, glandular, melanocytic, and mesenchymal tumors. Squamous carcinoma is by far the most common primary malignancy involving both organs and is related to human papillomavirus infection in the majority of cases. Squamous intraepithelial lesion is the most common preinvasive condition of squamous cell carcinoma. Conventional Mullerian adenocarcinomas are rare malignancies of the vulva and vagina. Extramammary Paget disease represents a special form of intraepithelial glandular malignancy and is only rarely associated with an invasive component. Primary clear cell carcinoma of the vagina has been famous for its association with intrauterine diethylstilbestrol (DES) exposure in the past but is very rare nowadays. Melanoma accounts for 5 % of vulvar cancers and is capable of widespread metastases. A variety of benign and malignant mesenchymal tumors also occur in the vulvar and vaginal regions with benign angiomyofibroblastoma and deep aggressive angiomyxoma primarily involving these areas.

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Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Pei Hui & Natalia Buza

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  1. Pei Hui
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  2. Natalia Buza
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© 2015 Springer International Publishing Switzerland

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Hui, P., Buza, N. (2015). Vulva and Vagina. In: Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-21807-6_2

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  • DOI: https://doi.org/10.1007/978-3-319-21807-6_2

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-21806-9

  • Online ISBN: 978-3-319-21807-6

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