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Tendon Stem Cell Niche

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Tissue-Specific Stem Cell Niche

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies. In this chapter, the main characteristics of their microenvironment—niche —are reviewed. In particular, the importance of signaling molecules and extracellular matrix (ECM) are highlighted, focusing on their potential role in tendon regeneration.

The original version of this chapter was revised: The spelling of the first author’s name was corrected. The erratum to this chapter is available at DOI 10.1007/978-3-319-21705-5_14

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-21705-5_14

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Abbreviations

α-SMA:

Alpha smooth muscle actin

BMSCs:

Bone marrow-derived mesenchymal stem cells

CD:

Cluster of differentiation

COMP:

Collagen oligomeric matrix protein

Cx:

Connexin

ECM:

Extracellular matrix

Egr 1:

Early growth response 1 transcription factor

Egr 2:

Early growth response 2 transcription factor

EGF:

Epidermal growth factor

FGF:

Fibroblast growth factor

GAGs:

Glycosaminoglycans

GDF-5:

Growth differentiation factor 5

GFs:

Growth factors

IGF:

Insulin-like growth factor

MHC-II:

Major histocompatibility complex II

Mkx:

Mohawk

MSCs:

Mesenchymal stem cells

PDGF-BB:

Platelet derived growth factor

PLs:

Platelet lysates

PGs:

Proteoglycans

PRP:

Platelet-rich plasma

Scx:

Scleraxis

TGF-β:

Transforming growth factor-beta

TDSCs:

Tendon-derived stem cells

TFs:

Transcription factors

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Authors and Affiliations

  1. 3B’s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco GMR, 4805-017, Guimarães, Portugal

    Raquel Costa-Almeida, A. I. Gonçalves, P. Gershovich, M. T. Rodrigues, R. L. Reis & M. E. Gomes

  2. ICVS/3B’s Government Associate Laboratory, University of Minho, Braga, Portugal

    Raquel Costa-Almeida, A. I. Gonçalves, P. Gershovich, M. T. Rodrigues, R. L. Reis & M. E. Gomes

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  1. Raquel Costa-Almeida
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  2. A. I. Gonçalves
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  3. P. Gershovich
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  4. M. T. Rodrigues
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  5. R. L. Reis
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    Kursad Turksen

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Costa-Almeida, R., Gonçalves, A.I., Gershovich, P., Rodrigues, M.T., Reis, R.L., Gomes, M.E. (2015). Tendon Stem Cell Niche. In: Turksen, K. (eds) Tissue-Specific Stem Cell Niche. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21705-5_10

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