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An Overview of Treatment for Cervical Cancer with Emphasis on Immune Cell-Based Therapies

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International Manual of Oncology Practice

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Abstract

Cervical cancer, the third most common cancer in women worldwide, has an incidence of 80 % in the developing countries. Relatively, the women in developing nations are diagnosed at an advanced stage of the disease due to disparities in screening programs and other socio-economic factors. Although surgery and/or chemo, radiotherapies are indicated for early stage cervical cancers, in the advanced stages, palliative management continues to be the mainstay approach. Recent approaches exploring targeted therapies that act on receptors, signalling pathways, molecules deserve a mention. Autologous immune-cell-based immunotherapies for cancer have been in clinical practice for more than three decades in countries like Japan for various solid tumors including cervical cancer. The cell based immunotherapies employ dendritic Cells, γδ T cells (gamma delta T cells) natural killer (NK) cells, NKT cells, activated T lymphocytes, cytotoxic T lymphocytes (CTLs) and lymphokine activated killer (LAK) cells. NK cells are of particular interest due to their rapid response against cancer cells and virus-infected cells even without being sensitized to antigens to kill cells that are missing the “self” markers of the major histocompatibility complex (MHC) class I. With human papilloma virus (HPV) being associated with virtually all the cases of cervical cancer, NK cell immunotherapy gathers more importance as it acts as a common weapon against the virus and cancer cells. With vaccination against HPV now being available, immunological considerations in cervical cancer gain significance and form a major arena for future research. This chapter will provide an overview on the existing treatment options for cervical cancer with special emphasis on the cell-based immunotherapies.

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Authors and Affiliations

  1. The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai, 600034, Tamil Nadu, India

    Samuel J. K. Abraham, Vidyasagar Devaprasad Dedeepiya & Senthilkumar Preethy

  2. Faculty of Medicine, Yamanashi University, Chuo, Japan

    Samuel J. K. Abraham

  3. Biotherapy Institute of Japan, Tokyo, Japan

    Hiroshi Terunuma

  4. Chennai Meenakshi Multispeciality Hospital Limited, Chennai, India

    Sumana Premkumar

  5. Dr. Kamakshi Memorial Hospital, Chennai, India

    Sumana Premkumar

Authors
  1. Samuel J. K. Abraham
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  2. Hiroshi Terunuma
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  3. Vidyasagar Devaprasad Dedeepiya
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  4. Sumana Premkumar
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  5. Senthilkumar Preethy
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Corresponding author

Correspondence to Samuel J. K. Abraham .

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Editors and Affiliations

  1. Medical Oncology, University of Algarve, Faro, Portugal

    Ramon Andrade de Mello

  2. edificio 7, ala nascente, 3º andar, University of Algarve, Dept Cie Biomed edificio 7, ala nascente, 3º andar, Faro, Portugal

    Álvaro Tavares

  3. Medical Oncology, University of Athens, Athens, Greece

    Giannis Mountzios

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Abraham, S.J.K., Terunuma, H., Dedeepiya, V.D., Premkumar, S., Preethy, S. (2015). An Overview of Treatment for Cervical Cancer with Emphasis on Immune Cell-Based Therapies. In: de Mello, R., Tavares, Á., Mountzios, G. (eds) International Manual of Oncology Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-21683-6_44

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