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The Molecular and Cellular Mechanisms of Zebrafish Lateral Line Development

  • Hillary F. McGraw
  • Catherine M. Drerup
  • Teresa Nicolson
  • Alex V. NechiporukEmail author
Chapter
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 64)

Abstract

In aquatic vertebrates, the lateral line mechanosensory system allows for sensation of changes in water current and mediates such behaviors as schooling, predator avoidance, and mating. The lateral line forms from placodes that arise just rostral and caudal to the otic placode. Shortly after placode formation, groups of cells will delaminate from the placodes and begin migrating either throughout the head or down the trunk of the developing embryo. These migratory groups of cells are known as the sensory ridges (head) and posterior lateral line primordium (trunk). During migration, they deposit cell clusters containing hair cell precursors. Shortly after deposition, these clusters will differentiate into mechanosensory organs called neuromasts. In larvae and adults, the lateral line system continues to elaborate; this is accomplished through a differentiation of latent precursors (larvae) as well as a cellular budding process (larvae and adults), resulting in strings of neuromasts that populate the body of aquatic vertebrates. The zebrafish (Danio rerio) has emerged as an exquisite model to study the formation and function of the lateral line system. This chapter describes the development of the zebrafish lateral line and the associated axonal innervations that make up the mechanosensory system.

Keywords

Cranial placodes Development Fibroblast growth factor signaling Lateral line ganglion Mechanosensory hair cells Neuromast Primordium Wnt signaling 

Notes

Compliance with Ethics Requirements

Catherine M. Drerup declares no competing financial or ethical interests.

Hillary F. McGraw declares no competing financial or ethical interests.

Alex V. Nechiporuk declares no competing financial or ethical interests.

Teresa Nicolson declares no competing financial or ethical interests.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Hillary F. McGraw
    • 1
  • Catherine M. Drerup
    • 2
  • Teresa Nicolson
    • 3
  • Alex V. Nechiporuk
    • 4
    Email author
  1. 1.Division of Cell Biology and BiophysicsUniversity of Missouri Kansas CityKansas CityUSA
  2. 2.Division of Developmental BiologyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA
  3. 3.Vollum InstituteOregon Health & Science UniversityPortlandUSA
  4. 4.Department of CellDevelopmental and Cancer Biology, Oregon Health & Science UniversityPortlandUSA

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