Abstract
In spinal cord stimulation (SCS) therapy neuromodulation leads are interacting with human dura during and after their implantations. Knowledge of the mechanical properties of spinal cord with meninges is essential for lead design, development, and optimization. In this study, an in-vivo indentation test method was developed to assess the equivalent Young’s Modulus of sheep spinal cord with meninges. Histological analysis of the spinal cord with meninges was conducted. In-vivo equivalent Young’s Modulus was compared with published Young’s Modulus of cadaver dura and spinal cord respectively. The equivalent modulus has a mean of 0.022 MPa and a standard deviation of 0.014 MPa. Compared to the elastic modulus of spinal cord and the elastic modulus of dura mater, the equivalent elastic modulus of spinal cord with meninges is much smaller.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Manchikanti, L., Boswell, M.V., et al.: Comprehensive review of therapeutic interventions in managing chronic spinal pain. Pain Physician 24, E123–E198 (2009)
Barolat, G., Sharan, A.D.: Spinal cord stimulation for chronic pain management. Semin. Neurosurg. 15(2/3), 151–175 (2004)
Cameron, T.: Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. J. Neurosurg. Spine 100, 254–267 (2004)
Manchikanti, A., Boswell, M., Datta, S., Fellows, B., Abdi, S., Vijay, V., Benyamin, R., Falco, F., Helm, S., Hayek, S., Smith, H.: Comprehensive review of therapeutic interventions in managing chronic spinal pain. Pain Physician 12, E123–E198 (2009)
Chang, G., Hung, T., Bleyaert, A., Jannetta, P.: Stress–strain measurement of the spinal cord of puppies and their neurological evaluation. J. Trauma. 21, 807–810 (1981)
Hung, T., Chang, G.: Biomechanical and neurological response of the spinal cord of a puppy to uniaxial tension. J. Biomech. Eng. 103, 43–47 (1981)
Hung, T., Chang, G., Lin, H., Walter, F., Bunegin, L.: Stress–strain relationship of the spinal cord of anesthetized cats. J. Biomech. 14, 269–276 (1981)
Chang, G., Hung, T., Feng, W.: An in-vivo measurement and analysis of viscoelastic properties of the spinal cords of cats. J. Biomech. Eng. 110, 115–122 (1988)
Van Noort, R., Black, M., Martin, T., Meanley, S.: A study of the uniaxial mechanical properties of human dura mater preserved in glycerol. Biomaterials 2, 41–45 (1981)
Breig, A.: Biomechanics of the Central Nervous System. Almzvist & Wiksell, Stockholm (1960)
Bilston, L., Thibault, L.: The mechanical properties of the human cervical spinal cord in vitro. Ann. Biomed. Eng. 24, 67–74 (1995)
Mazuchowski, E., Thibault, L.: Biomechanical properties of the human spinal cord and pia mater. Summer Bioengineering Conference, Sonesta Beach Resort in Key Biscayne, Florida, 25–29 June 2003
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 The Society for Experimental Mechanics, Inc.
About this paper
Cite this paper
Zhang, H., Falkner, P., Cai, C. (2016). In-Vivo Indentation Testing of Sheep Spinal Cord with Meninges. In: Tekalur, S., Zavattieri, P., Korach, C. (eds) Mechanics of Biological Systems and Materials, Volume 6. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, Cham. https://doi.org/10.1007/978-3-319-21455-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-319-21455-9_11
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-21454-2
Online ISBN: 978-3-319-21455-9
eBook Packages: EngineeringEngineering (R0)