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In-Silico Models of Trabecular Bone: A Sensitivity Analysis Perspective

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Uncertainty in Biology

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 17))

Abstract

This chapter provides an overview from a sensitivity analysis perspective of computational mechanical modeling of trabecular bone, where models are generated from Computed Tomography images. Specifically, the effect of model development choices on the model results is systematically reviewed and analyzed for both micro-Finite Element and continuum-Finite Element models. Particular emphasis is placed on the image processing effects (thresholding, down-sampling, image to material properties relationships), the mesh-related aspects (mesh size, element type), and the computational representation of the boundary conditions. Typical issues are highlighted and recommendations are proposed with respect to various model applications, including global stiffness/strength and local failure stress/strain behavior.

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Authors and Affiliations

  1. Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK

    Marlène Mengoni, Sebastien Sikora, Ruth Karen Wilcox & Alison Claire Jones

  2. Department of Aerospace and Mechanical Engineering, Non-Linear Computational Mechanics (LTAS-MN²L), University of Liege, Liège, Belgium

    Marlène Mengoni & Vinciane d’Otreppe

Authors
  1. Marlène Mengoni
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  2. Sebastien Sikora
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  3. Vinciane d’Otreppe
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  4. Ruth Karen Wilcox
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  5. Alison Claire Jones
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Corresponding author

Correspondence to Marlène Mengoni .

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Editors and Affiliations

  1. Biomechanics Research Unit, University of Liège, Liège 1, Belgium

    Liesbet Geris

  2. Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

    David Gomez-Cabrero

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Mengoni, M., Sikora, S., d’Otreppe, V., Wilcox, R.K., Jones, A.C. (2016). In-Silico Models of Trabecular Bone: A Sensitivity Analysis Perspective. In: Geris, L., Gomez-Cabrero, D. (eds) Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_15

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  • DOI: https://doi.org/10.1007/978-3-319-21296-8_15

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