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Sensitivity Analysis by Design of Experiments

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Uncertainty in Biology

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 17))

Abstract

The design of experiments (DOE) is a valuable method for studying the influence of one or more factors on the outcome of computer experiments. There is no limit to the number of times a computer experiment can be run, but they are often time-consuming. Moreover, the number of parameters in a computer model is often very large and the range of variation for each of these parameters is often quite extensive. The DOE provides the statistical tools necessary for choosing a minimum amount of parameter combinations resulting in as much information as possible about the computer model. In this chapter, several designs and analysing methods are explained. At the end of the chapter, these designs and methods are applied to a mechanobiological model describing tooth movement.

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Acknowledgments

The authors acknowledge support from European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement n279100 (An Van Schepdael and Liesbet Geris). Aurélie Carlier is a Fellow of the Research Foundation Flanders (FWO).

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Authors and Affiliations

  1. Biomechanics Research Unit, University of Liège, Chemin des Chevreuils 1-BAT 52/3, 4000, Liège, Belgium

    An Van Schepdael & Liesbet Geris

  2. Biomechanics Section, University of Leuven, Celestijnenlaan 300C, Box 2419, 3001, Heverlee, Belgium

    Aurélie Carlier

Authors
  1. An Van Schepdael
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  2. Aurélie Carlier
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  3. Liesbet Geris
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Correspondence to Liesbet Geris .

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Editors and Affiliations

  1. Biomechanics Research Unit, University of Liège, Liège 1, Belgium

    Liesbet Geris

  2. Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

    David Gomez-Cabrero

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The authors declare that they have no conflict of interest.

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Van Schepdael, A., Carlier, A., Geris, L. (2016). Sensitivity Analysis by Design of Experiments. In: Geris, L., Gomez-Cabrero, D. (eds) Uncertainty in Biology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-21296-8_13

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  • DOI: https://doi.org/10.1007/978-3-319-21296-8_13

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-21296-8

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