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T Cell Modulation: Anti-PD-1 Antibodies for the Treatment of Cancer

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Book cover Developments in T Cell Based Cancer Immunotherapies

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The expression of inhibitory receptors on tumor specific T cells leads to compromised effector function such as decreased proliferation, cytokine secretion, and tumor cell lysis. These receptors can be targeted therapeutically using monoclonal antibodies, an approach that was termed “checkpoint blockade”. The improved survival of advanced melanoma patients treated with the anti-CTLA-4 antibody ipilimumab validates this new treatment concept. Inhibition of another inhibitory pathway, PD-1/PD-L1, using monoclonal antibodies has recently shown much promise in the treatment of melanoma, renal cell cancer, non-small cell lung cancer, among other tumor types. Durable anti-tumor activity with a favorable safety profile has lead to fast paced clinical development of many compounds targeting both PD-1 and PD-L1.

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Authors and Affiliations

  1. Dana Farber Cancer Institute, Harvard Medical School, Melanoma Disease Center and Center for Immuno-Oncology, 450 Brookline Avenue, Boston, MA, 02215-5450, USA

    Patrick A. Ott M.D., Ph.D. & F. Stephen Hodi

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  1. Patrick A. Ott M.D., Ph.D.
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  2. F. Stephen Hodi
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Correspondence to Patrick A. Ott M.D., Ph.D. .

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Editors and Affiliations

  1. Unit of Melanoma & Cancer Immunotherapy, National Tumor Institute Fondazione G., Naples, Italy

    Paolo A. Ascierto

  2. Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA

    David F. Stroncek

  3. Department of Transfusion Medicine, National Institutes of Health, BETHESDA, Maryland, USA

    Ena Wang

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Ott, P.A., Hodi, F.S. (2015). T Cell Modulation: Anti-PD-1 Antibodies for the Treatment of Cancer. In: Ascierto, P., Stroncek, D., Wang, E. (eds) Developments in T Cell Based Cancer Immunotherapies. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-21167-1_10

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  • DOI: https://doi.org/10.1007/978-3-319-21167-1_10

  • Publisher Name: Humana Press, Cham

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  • Online ISBN: 978-3-319-21167-1

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