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MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC)

  • Daniel Lee MillerEmail author
  • M. Sharon Stack
Chapter

Abstract

The tumorigenesis pathways and molecular etiologies of head and neck squamous cell carcinoma (HNSCC) have been studied extensively, however it remains a very difficult disease to treat and cure. Further, there is a paucity of clinically applicable diagnostic platforms that significantly improve detection rates and patient outcomes. Early detection of locally confined cancers promises the ability to improve patient outcomes by providing less invasive surgical treatments. Indeed, patients at high risk of treatment failure should be appropriately stratified and treated compared to those with relatively low-risk profiles. This promise, together with the ability to classify disease according to a panel of phenotypic and genotypic markers in order to select the optimal treatment modality, is the fundamental premise of the emerging field of “precision medicine.” In this chapter, we summarize recent data on microRNA profiling of human papillomavirus positive (HPV+) HNSCC, predominantly localized in the oropharynx (OPSCC), discuss potential targets of these microRNAs, and examine the potential utility of microRNAs as biomarkers and therapeutic targets in HPV+ OPSCC.

Keywords

HPV Microrna Immune system Biomarker 

Notes

Acknowledgments

This work was supported in part by research grant RO1085870 (MSS) from the National Institutes of Health/National Cancer Institute, a RL Kirschstein National Research Service Award F31 DE021926 (DLM) from the National Institute of Dental and Craniofacial Research, and an Advancing Basic Cancer research grant from the Walther Cancer Foundation (MSS).

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Pathology and Anatomical SciencesUniversity of Missouri School of MedicineColumbiaUSA
  2. 2.Department of Chemistry and BiochemistryHarper Cancer Research InstituteSouth BendUSA

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