HPV Virology: Cellular Targets of HPV Oncogenes and Transformation

  • Eric A. SmithEmail author
  • Marie C. Matrka
  • Susanne I. Wells


A subtype of head and neck cancer (HNC) characterized by infection with human papillomavirus (HPV) is clinically and molecularly distinct from classical HNC. In general these tumors arise in younger patients and respond better to therapy, while also expressing wild-type tumor suppressor proteins. Owing to these observations, efforts are currently being made to understand HPV+ HNC biology to improve clinical treatment regimens and develop novel therapeutic agents. To best predict which treatment strategies and novel therapeutics will have the most impact in patient care, a working understanding of how the HPV arsenal of oncogenes manipulates and transforms cells is crucial. This chapter will highlight the most important and clinically interesting cellular targets of the HPV oncogenes; the mechanisms by which the viral oncogenes subvert cell cycle checkpoints, DNA repair, immune surveillance, and cell death to promote malignant transformation; and promising future therapeutic options to target the functions of HPV oncogenes.


HPV E2 E5 E6 E7 Head and neck cancer DNA repair Mitosis Immune evasion Transformation 



This work was funded by two NIH awards: RO1 CA116316 and CA102357. Special thanks are given to Timothy Chlon for his critical input and discussion of the manuscript.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Eric A. Smith
    • 1
    Email author
  • Marie C. Matrka
    • 1
  • Susanne I. Wells
    • 1
  1. 1.Cincinnati Children’s Hospital Medical CenterCincinnatiUSA

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