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Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas

  • Teresa A. AndersonEmail author
  • Aaron C. Ermel
Chapter
  • 676 Downloads

Abstract

There is a well-recognized subset of head and neck squamous cell carcinomas (HNSCC) that are associated with HPV infection. These cancers differ from traditional HNSCC in that they occur in younger individuals and have decreased association with tobacco and alcohol use. Many studies have looked at the behavioral correlates associated with this subset of cancers. The most commonly reported sexual behaviors associated with this subset of HNSCC include increased number of lifetime vaginal or oral sex partners, younger age at sexual debut, oral-anal sex partners, history of other sexually transmitted infections and same-sex sexual partners. Nonsexual behaviors including tobacco use, alcohol use, marijuana use, nutrition and dental health have less consistent data supporting association with this subset of HNSCC. Understanding of the behavioral factors contributing to oral HPV DNA detection and development of HPV-associated HNSCC has increased significantly over the years, but further studies are needed to delineate the main contributors to develop effective interventions.

Keywords

Oropharyngeal Squamous Cell Carcinoma Oral Cavity Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Applebaum KM, Furniss CS, Zeka A, Posner MR, Smith JF, Bryan J et al (2007) Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst 99(23):1801–1810PubMedCrossRefGoogle Scholar
  2. Antonsson A, Cornford M, Perry S, Davis M, Dunne MP, Whiteman DC (2014) Prevalence and risk factors for oral HPV infection in young australians. PLoS ONE 9(3):e91761PubMedCentralPubMedCrossRefGoogle Scholar
  3. Arthur AE, Duffy SA, Sanchez GI, Gruber SB, Terrell JE, Hebert JR et al (2011) Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis. Nutr Cancer 63(5):734–742PubMedCentralPubMedCrossRefGoogle Scholar
  4. Beachler DC, Weber KM, Margolick JB, Strickler HD, Cranston RD, Burk RD et al (2012) Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults. Cancer epidemiol, biomarkers and prev : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(1):122–133 Epub 2011/11/03CrossRefGoogle Scholar
  5. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E et al (2011) Human papillomavirus and risking oropharyngeal cancer incidence in the United States. J Clin Oncol 29(32):4294–4301PubMedCentralPubMedCrossRefGoogle Scholar
  6. Colón-López V, Ortiz AP, Del Toro-Mejías L, Clatts MC, Palefsky JM (2014) Epidemiology of anal HPV infection in high-risk men attending a sexually transmitted infection clinic in puerto rico. PLoS ONE 9(1):e83209PubMedCentralPubMedCrossRefGoogle Scholar
  7. Crawford R, Grignon A-L, Kitson S, Winder DM, Ball SL, Vaughan K et al (2011) High prevalence of HPV in non-cervical sites of women with abnormal cervical cytology. BMC Cancer 11(1):473PubMedCentralPubMedCrossRefGoogle Scholar
  8. Dahlstrom KR, Li GJ, Tortolero-Luna G, Wei QY, Sturgis EM (2011) Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites. Head Neck-J Sci Spec 33(6):847–855CrossRefGoogle Scholar
  9. D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM et al (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956PubMedCrossRefGoogle Scholar
  10. D’Souza G, Agrawal Y, Halpern J, Bodison S, Gillison ML (2009) Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis 199(9):1263–1269 Epub 2009/03/27PubMedCrossRefGoogle Scholar
  11. Fakhry C, D’souza G, Sugar E, Weber K, Goshu E, Minkoff H, et al. (2006) Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and-negative women. J Clin Microbiol 44(12):4479–85Google Scholar
  12. Fernandez Garrote L, Herrero R, Ortiz Reyes R, Vaccarella S, Lence Anta J, Ferbeye L et al. (2001) Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer 85(1):46–54Google Scholar
  13. Ji X, Neumann AS, Sturgis EM, Adler-Storthz K, Dahlstrom KR, Schiller JT et al (2008) p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers. Carcinogenesis 29(4):875–879PubMedCrossRefGoogle Scholar
  14. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92(9):709–720PubMedCrossRefGoogle Scholar
  15. Gillison ML, D’Souza G, Westra W, Sugar E, Xiao W, Begum S et al (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100(6):407–420 Epub 2008/03/13PubMedCrossRefGoogle Scholar
  16. Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W, Kahle L et al (2012a) Prevalence of oral HPV infection in the United States, 2009–2010. JAMA 307(7):693–703 Epub 2012/01/28PubMedCrossRefGoogle Scholar
  17. Gillison ML, Alemany L, Snijders PJ, Chaturvedi A, Steinberg BM, Schwartz S et al (2012b) Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis. Vaccine 30:F34–F54PubMedCrossRefGoogle Scholar
  18. Giuliano AR, Tortolero-Luna G, Ferrer E, Burchell AN, de Sanjose S, Kjaer SK et al (2008) Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine 26:K17–K28PubMedCentralPubMedCrossRefGoogle Scholar
  19. Heck JE, Berthiller J, Vaccarella S, Winn DM, Smith EM, Shan’gina O et al (2010) Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol 39(1):166–181 Epub 2009/12/22PubMedCentralPubMedCrossRefGoogle Scholar
  20. Herrero R, Castellsague X, Pawlita M, Lissowska J, Kee F, Balaram P et al (2003) Human papillomavirus and oral cancer: the international agency for research on cancer multicenter study. J Natl Cancer Inst 95(23):1772–1783 Epub 2003/12/05PubMedCrossRefGoogle Scholar
  21. Kreimer AR, Alberg AJ, Daniel R, Gravitt PE, Viscidi R, Garrett ES et al (2004) Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis 189(4):686–698PubMedCrossRefGoogle Scholar
  22. Kreimer AR, Clifford GM, Boyle P, Franceschi S (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidem Biomar 14(2):467–475CrossRefGoogle Scholar
  23. Kreimer AR, Pierce Campbell CM, Lin H-Y, Fulp W, Papenfuss MR, Abrahamsen M et al (2013) Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet 382(9895):877–887CrossRefGoogle Scholar
  24. Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH et al (2009) A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Cancer Prev Res 2(8):759–768CrossRefGoogle Scholar
  25. Lissowska J, Pilarska A, Pilarski P, Samolczyk-Wanyura D, Piekarczyk J, Bardin-Mikollajczak A et al (2003) Smoking, alcohol, diet, dentition and sexual practices in the epidemiology of oral cancer in Poland. Eur J cancer prev: the official journal of the European cancer prevention organisation 12(1):25–33 Epub 2003/01/28CrossRefGoogle Scholar
  26. Maden C, Beckmann AM, Thomas DB, McKnight B, Sherman KJ, Ashley RL et al (1992) Human papillomaviruses, herpes simplex virues, and the risk of oral cancer in men. Am J Epidemiol 135(10):1093–1102PubMedGoogle Scholar
  27. Meyer MS, Applebaum KM, Furniss CS, Peters ES, Luckett BG, Smith JF et al (2008) Human papillomavirus-16 modifies the association between fruit consumption and head and neck squamous cell carcinoma. Cancer Epidem Biomar 17(12):3419–3426CrossRefGoogle Scholar
  28. Pavia M, Pileggi C, Nobile CG, Angelillo IF (2006) Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr 83(5):1126–1134PubMedGoogle Scholar
  29. Pickard RK, Xiao W, Broutian TR, He X, Gillison ML (2012) The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sex Transm Dis 39(7):559–566PubMedCrossRefGoogle Scholar
  30. Rajkumar T, Sridhar H, Balaram P, Vaccarella S, Gajalakshmi V, Nandakumar A et al (2003) Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices. Eur J Cancer Prev: the official journal of the European Cancer Prevention Organisation 12(2):135–143 Epub 2003/04/03CrossRefGoogle Scholar
  31. Ribeiro KB, Levi JE, Pawlita M, Koifman S, Matos E, Eluf-Neto J et al (2011) Low human papillomavirus prevalence in head and neck cancer: results from two large case–control studies in high-incidence regions. Int J Epidemiol 40(2):489–502PubMedCrossRefGoogle Scholar
  32. Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM et al (1998) Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 90(21):1626–1636PubMedCrossRefGoogle Scholar
  33. Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang D et al (2004a) Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer Journal international du cancer 108(5):766–772 Epub 2003/12/30PubMedCrossRefGoogle Scholar
  34. Smith EM, Ritchie JM, Summersgill KF, Hoffman HT, Wang DH, Haugen TH et al (2004b) Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. JNCI J Nat Cancer Inst 96(6):449–455PubMedCrossRefGoogle Scholar
  35. Smith EM, Swarnavel S, Ritchie JM, Wang D, Haugen TH, Turek LP (2007) Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents. Pediatr Infect Dis J 26(9):836–840PubMedCrossRefGoogle Scholar
  36. Smith EM, Rubenstein LM, Haugen TH, Hamsikova E, Turek LP (2010) Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers. Cancer Causes Control 21(9):1369–1378PubMedCrossRefGoogle Scholar
  37. Smith EM, Rubenstein LM, Haugen TH, Pawlita M, Turek LP (2012) Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease. J Oncol 116(2): 514–519Google Scholar
  38. Steinau M, Hariri S, Gillison ML, Broutian TR, Dunne EF, Tong ZY, et al. (2014) Prevalence of cervical and oral human papillomavirus infections among us women. J Infect Dis 209(11):1739-43 Epub 2013/12/10Google Scholar
  39. Tachezy R, Klozar J, Salakova M, Smith E, Turek L, Betka J et al (2005) HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic. Oral Dis 11(3):181–185PubMedCrossRefGoogle Scholar
  40. Talamini R, Vaccarella S, Barbone F, Tavani A, La Vecchia C, Herrero R et al (2000) Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer 83(9):1238–1242PubMedCentralPubMedCrossRefGoogle Scholar
  41. Tezal M, Nasca MS, Stoler DL, Melendy T, Hyland A, Smaldino PJ et al (2009) Chronic periodontitis—human papillomavirus synergy in base of tongue cancers. Arch Otolaryngol-Head and Neck Surg 135(4):391–396CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Infectious DiseasesIndiana University School of MedicineIndianapolisUSA

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