Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas

  • Teresa A. AndersonEmail author
  • Aaron C. Ermel


There is a well-recognized subset of head and neck squamous cell carcinomas (HNSCC) that are associated with HPV infection. These cancers differ from traditional HNSCC in that they occur in younger individuals and have decreased association with tobacco and alcohol use. Many studies have looked at the behavioral correlates associated with this subset of cancers. The most commonly reported sexual behaviors associated with this subset of HNSCC include increased number of lifetime vaginal or oral sex partners, younger age at sexual debut, oral-anal sex partners, history of other sexually transmitted infections and same-sex sexual partners. Nonsexual behaviors including tobacco use, alcohol use, marijuana use, nutrition and dental health have less consistent data supporting association with this subset of HNSCC. Understanding of the behavioral factors contributing to oral HPV DNA detection and development of HPV-associated HNSCC has increased significantly over the years, but further studies are needed to delineate the main contributors to develop effective interventions.


Oropharyngeal Squamous Cell Carcinoma Oral Cavity Cancer 
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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Infectious DiseasesIndiana University School of MedicineIndianapolisUSA

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