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The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-Associated Oropharyngeal Cancer

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Book cover Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

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Abstract

Human papillomavirus (HPV) is increasingly identified as a causative agent for oropharyngeal squamous cell carcinoma (OPSCC), often in relatively young patients lacking traditional carcinogenic risk factors such as tobacco and alcohol use. A growing body of literature has highlighted the importance of immune impairment in the pathogenesis of HPV-related premalignant and malignant lesions in the uterine cervix and, more recently, the oropharynx. This chapter will summarize current knowledge of the mechanisms that human papillomaviruses have evolved to evade the host immune system in the development of malignancy and will conclude with a discussion on preventive and therapeutic strategies that exploit these immune modulatory mechanisms.

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Authors and Affiliations

  1. Department of Otolaryngology, Eye & Ear Institute, University of Pittsburgh, Suite 500200 Lothrop St, Pittsburgh, PA, 15213, USA

    Nicole C. Schmitt, Robert L. Ferris & Seungwon Kim

Authors
  1. Nicole C. Schmitt
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  2. Robert L. Ferris
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  3. Seungwon Kim
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Corresponding author

Correspondence to Seungwon Kim .

Editor information

Editors and Affiliations

  1. School of Medicine, University of Missouri, Columbia, Missouri, USA

    Daniel L. Miller

  2. Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, Indiana, USA

    M. Sharon Stack

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© 2015 Springer International Publishing Switzerland

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Schmitt, N.C., Ferris, R.L., Kim, S. (2015). The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-Associated Oropharyngeal Cancer. In: Miller, D., Stack, M. (eds) Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-21100-8_13

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