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Neural Regulation of Lung Development

  • Chapter
Stem Cells in the Lung

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The respiratory system, comprising the lungs, trachea, vasculature, and associated neural tissues, carries out gas exchange essential for terrestrial life. During early embryonic development, the lung primordium, originating from the ventral foregut endoderm, bifurcates ventrolaterally to form two primary lung buds. Within these developing buds, the lung mesoderm interacts with the endoderm to generate various lineages, including airway smooth muscle, vasculature, and pericytes. As these buds progressively invade their surroundings to form the characteristic tree-like architecture of the lungs, an extensive neuronal network develops concomitantly. This developing neural network will become essential to control breathing and relay sensation to the central nervous system. Here, we summarize what is known about the embryogenesis of intrinsic and extrinsic lung innervation and how it impacts on lung development. However, the precise ontogeny of the respiratory neuronal network and the signals by which it is regulated are, as yet, not fully elucidated.

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Authors and Affiliations

  1. Stem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

    Alan J. Burns Ph.D., Lucy J. Freem & Jean-Marie Delalande

  2. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

    Alan J. Burns Ph.D.

  3. Division of Developmental Biology, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK

    Lucy J. Freem

  4. Centre for Digestive Diseases, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Jean-Marie Delalande

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  1. Alan J. Burns Ph.D.
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  2. Lucy J. Freem
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  3. Jean-Marie Delalande
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Correspondence to Alan J. Burns Ph.D. .

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Editors and Affiliations

  1. Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia

    Ivan Bertoncello

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Burns, A.J., Freem, L.J., Delalande, JM. (2015). Neural Regulation of Lung Development. In: Bertoncello, I. (eds) Stem Cells in the Lung. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21082-7_4

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