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Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis

  • Chapter
Book cover Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

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Abstract

Accumulating evidence shows the presence of a subpopulation of cancer stem cells (CSCs) in many cancers including breast cancer. The breast cancer stem cells (BCSC) are resistant to traditional treatments and able to initiate tumorigenesis, suggesting that they may contribute to therapy resistance and relapse. The expression of specific markers in BCSCs and development of mouse model has facilitated the study and several intrinsic and extrinsic pathways maintaining BCSC population have been exploited. Several signal transduction pathways such as Wnt, Notch, Hedgehog, Bmi-1, PI3K/AKT and IL6 are known to regulate self-renewal pathways in normal stem cells; while in CSCs these pathways are normally dysregulated due to accumulated mutations and epigenetic changes. Understanding the signaling pathways through which CSCs regulate their self-renewal and maintenance, and hence tumor growth and metastasis is important for developing targeted therapies to abrogate CSCs.

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Authors and Affiliations

  1. Innovation Center for Cell Biology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, China

    Lu Deng, Jiahui Xu, Dong Wang & Suling Liu

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  1. Lu Deng
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  2. Jiahui Xu
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  3. Dong Wang
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  4. Suling Liu
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Correspondence to Suling Liu .

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Editors and Affiliations

  1. Faculty of Biol. Scs. Dept. of Mol. Gen., Tarbiat Modares University , Tehran, Iran

    Sadegh Babashah

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Deng, L., Xu, J., Wang, D., Liu, S. (2015). Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis. In: Babashah, S. (eds) Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-21030-8_6

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