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Progressive Multiple Sclerosis (SP and PP MS)

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Optical Coherence Tomography in Multiple Sclerosis

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Abstract

Approximately half of all multiple sclerosis patients develop a progressive disease course. How the progressive accumulation of clinical symptoms eclipses relapse-associated damage is unknown. Despite the high number of patients with progressive disease course, comparatively little is known about changes in the visual system of these patients. In this chapter we will review optical coherence tomography of retinal changes occurring in eyes from patients with primary and secondary progressive multiple sclerosis. We will review data on retinal nerve fiber layer changes but also discuss potential intraretinal findings. We will then discuss evidence for an association of retinal changes with clinical and brain correlates of disease activity. Finally, we will review data on longitudinal changes.

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Authors and Affiliations

  1. Department of Neurology, NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin, Germany

    Friedemann Paul MD & Alexander U. Brandt MD

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  1. Friedemann Paul MD
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  2. Alexander U. Brandt MD
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Correspondence to Friedemann Paul MD .

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Editors and Affiliations

  1. Department of Neuroimmunology, VU Medical Center, Expertise Center Neuro-ophthalmology, Departments of Neurology and Ophthalmology, Amsterdam, The Netherlands, Moorfields Eye Hospital, Department of Neuro-Ophthalmology, London, UK, UCL Institute of Neurology, London, United Kingdom

    Axel Petzold

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Paul, F., Brandt, A.U. (2016). Progressive Multiple Sclerosis (SP and PP MS). In: Petzold, A. (eds) Optical Coherence Tomography in Multiple Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-20970-8_9

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  • DOI: https://doi.org/10.1007/978-3-319-20970-8_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20969-2

  • Online ISBN: 978-3-319-20970-8

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