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Monitoring Treatment in Multiple Sclerosis

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Optical Coherence Tomography in Multiple Sclerosis

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Abstract

Approximately 20 % of patients with multiple sclerosis (MS) develop acute multiple sclerosis associated optic neuritis (MSON) as the initial symptom of their disease, and half of MS patients suffer acute MSON during the course of their disease. Even so, almost all MS patients have evidence of optic nerve demyelination at autopsy, indicating that occult, subclinical optic nerve demyelination occurs in virtually all MS patients. In agreement with these neuropathologic findings, the Optic Neuritis Treatment Trial (ONTT) showed evidence that subclinical or asymptomatic optic neuropathy was present in a significant proportion of fellow “unaffected” eyes at the time of enrolment in the ONTT and at 10 years follow-up.

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Authors and Affiliations

  1. Neuroimmunology & Multiple Sclerosis Program, Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Shin C. Beh MD

  2. Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

    Teresa C. Frohman PA-C

  3. Departments of Neurology and Ophthalmology, Multiple Sclerosis and Neuroimmunology Program and Clinical Center for Multiple Sclerosis, University of Texas Southwestern School of Medicine, Dallas, TX, USA

    Elliot M. Frohman MD, PhD, FAAN

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  1. Shin C. Beh MD
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  2. Teresa C. Frohman PA-C
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  3. Elliot M. Frohman MD, PhD, FAAN
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Correspondence to Shin C. Beh MD .

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Editors and Affiliations

  1. Department of Neuroimmunology, VU Medical Center, Expertise Center Neuro-ophthalmology, Departments of Neurology and Ophthalmology, Amsterdam, The Netherlands, Moorfields Eye Hospital, Department of Neuro-Ophthalmology, London, UK, UCL Institute of Neurology, London, United Kingdom

    Axel Petzold

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Beh, S.C., Frohman, T.C., Frohman, E.M. (2016). Monitoring Treatment in Multiple Sclerosis. In: Petzold, A. (eds) Optical Coherence Tomography in Multiple Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-20970-8_11

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