Abstract
Post-thrombotic syndrome (PTS) is a debilitating long-term complication of deep vein thrombosis (DVT). Patients with PTS present with chronic lower extremity edema, hyperpigmentation, and, in advanced cases, venous ulceration. PTS results in substantial disability, loss of functional status, and health care expenditure. Compression therapy, including graduated compression stockings, comprises the cornerstone of PTS therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kahn SR, Comerota AJ, Cushman M, et al. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. 2014;130:1636–61.
Kahn SR, Shbaklo H, Lamping DL, et al. Determinants of health-related quality of life during the 2 years following deep vein thrombosis. J Thromb Haemost. 2008;6:1105–12.
Kahn SR. How I treat postthrombotic syndrome. Blood. 2009;114:4624–31.
Kahn SR, Shrier I, Julian JA, et al. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med. 2008;149:698–707.
Cohen JM, Akl EA, Kahn SR. Pharmacologic and compression therapies for postthrombotic syndrome: a systematic review of randomized controlled trials. Chest. 2012;141:308–20.
Lattimer CR, Azzam M, Kalodiki E, Makris GC, Geroulakos G. Compression stockings significantly improve hemodynamic performance in post-thrombotic syndrome irrespective of class or length. J Vasc Surg. 2013;58:158–65.
Levi M. A long-awaited small step forward in the management of the post-thrombotic syndrome. Thromb Haemost. 2008;99:463–4.
Kahn SR, Shrier I, Shapiro S, et al. Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial. CMAJ. 2011;183:37–44.
Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;(11):CD003230.
Hartung O, Otero A, Boufi M, et al. Mid-term results of endovascular treatment for symptomatic chronic nonmalignant iliocaval venous occlusive disease. J Vasc Surg. 2005;42:1138–44; discussion 1144.
Kahn SR, Shapiro S, Wells PS, et al. Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial. Lancet. 2014;383:880–8.
Enden T, Haig Y, Klow NE, et al. Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. Lancet. 2012;379:31–8.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Piazza, G., Hohlfelder, B., Goldhaber, S.Z. (2015). Post-thrombotic Syndrome: Recognizing and Treating a Debilitating Complication of Deep Vein Thrombosis. In: Handbook for Venous Thromboembolism. Springer, Cham. https://doi.org/10.1007/978-3-319-20843-5_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-20843-5_12
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-20842-8
Online ISBN: 978-3-319-20843-5
eBook Packages: MedicineMedicine (R0)