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Introduction to Fluorescence Sensing pp 301–358Cite as

Recognition Units

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Abstract

Recognition units are the key functional units of molecular sensors that are responsible for selective target recognition in the proper range of target concentrations. Multi-point non-covalent interactions with the target with desired affinity allow providing selective target binding from a mixture of different and sometimes closely related compounds. In this Chapter we discuss different binding units and the principles of their design, construction and performance. They range from small coordination compounds targeting small molecules and ions to macromolecules such as enzyme substrates, proteins, nucleic acids, macromolecular assemblies or even the living cells. Most versatile and efficient of them are the antibodies and their short fragments and nucleic acid aptamers. Different ligand binding proteins are efficient addressing specific targets, and peptide nucleic acids became the basis of new technologies of DNA detection. The readier is requested to perform several tasks and respond to several questions at the end of this Chapter.

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  1. Laboratory of Nanobiotechnology Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    Alexander P. Demchenko

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Demchenko, A.P. (2015). Recognition Units. In: Introduction to Fluorescence Sensing. Springer, Cham. https://doi.org/10.1007/978-3-319-20780-3_7

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