Abstract
Fluorescence is the only method with high versatility that in target detection can combine ex vivo and in vivo studies. It offers the testing that is simple in performance, low invasive and applicable to point-of-care conditions. The progress in nanotechnology brings to biosensors the possibility for constructing the microarrays for high throughput parallel measurements of many analytes and for integration of biosensors with microfluidics into lab-on-a-chip devices. Moreover, a combination of disease diagnosis and treatment has become possible, which brought the appearance of a new field in research and development, the theranostics. Present Chapter focuses on these issues. It terminates with “Sensing and thinking” section on the strategy of controlling the diagnostics and treatment by light.
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References
Abel L, Kutschki S, Turewicz M, Eisenacher M, Stoutjesdijk J, Meyer HE, Woitalla D, May C (2014) Autoimmune profiling with protein microarrays in clinical applications. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844(5):977–987
Accomasso L, Rocchietti EC, Raimondo S, Catalano F, Alberto G, Giannitti A, Minieri V, Turinetto V, Orlando L, Saviozzi S (2012) Fluorescent silica nanoparticles improve optical imaging of stem cells allowing direct discrimination between live and early-stage apoptotic cells. Small 8(20):3192–3200
Akerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E (2002) Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A 99(20):12617–12621
Aslan K, Geddes CD (2006) Microwave-accelerated and metal-enhanced fluorescence myoglobin detection on silvered surfaces: potential application to myocardial infarction diagnosis. Plasmonics 1(1):53–59
Badugu R, Lakowicz JR, Geddes CD (2004) Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens. Anal Chem 76(3):610–618
Batta A, Panag K, Singh J (2012) Cardiac markers–role in diagnosis of myocardial infarction. Int J Cur Bio Med Sci 2(2):262–267
Biffi S, Petrizza L, Rampazzo E, Voltan R, Sgarzi M, Garrovo C, Prodi L, Andolfi L, Agnoletto C, Zauli G (2014) Multiple dye-doped NIR-emitting silica nanoparticles for both flow cytometry and in vivo imaging. RSC Advances 4(35):18278–18285
Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T (2010) Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem Rev 110(5):2795–2838
Chen W, Xu N, Xu L, Wang L, Li Z, Ma W, Zhu Y, Xu C, Kotov NA (2010) Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics). Macromol Rapid Commun 31(2):228–236
Choi HS, Frangioni JV (2010) Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging 9(6):291
Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV (2007) Renal clearance of quantum dots. Nat Biotechnol 25(10):1165–1170
Christenson ES, Collinson PO, deFilippi CR, Christenson RH (2014) Heart failure biomarkers at point-of-care: current utilization and future potential. Expert Rev Mol Diagn 14(2):185–197
Chudakov DM, Lukyanov S, Lukyanov KA (2005) Fluorescent proteins as a toolkit for < i > in vivo</i > imaging. Trends Biotechnol 23(12):605–613
Clerc O, Greub G (2010) Routine use of point-of-care tests: usefulness and application in clinical microbiology. Clin Microbiol Infect 16(8):1054–1061
Culver HR, Daily AM, Khademhosseini A, Peppas NA (2014) Intelligent recognitive systems in nanomedicine. Curr Opin Chem Eng 4:105–113
Dayal S, Burda C (2008) Semiconductor quantum dots as two-photon sensitizers. J Am Chem Soc 130(10):2890–2891
Demchenko AP, Heldt J, Waluk J, Chou PT, Sengupta PK, Brizhik L, del Valle JC (2014) Michael Kasha: from photochemistry and flowers to spectroscopy and music. Angew Chem Int Ed 53(52):14316–14324
Devarajan P (2007) Emerging biomarkers of acute kidney injury. In: Acute kidney injury. Contrib Nephrol 156:203–212
Dong B, Xu S, Sun J, Bi S, Li D, Bai X, Wang Y, Wang L, Song H (2011) Multifunctional NaYF4: Yb 3+, Er 3 + @ Ag core/shell nanocomposites: integration of upconversion imaging and photothermal therapy. J Mater Chem 21(17):6193–6200
Dong Y, Wang R, Li H, Shao J, Chi Y, Lin X, Chen G (2012) Polyamine-functionalized carbon quantum dots for chemical sensing. Carbon 50(8):2810–2815. doi:10.1016/j.carbon.2012.02.046
Eisenblätter M, Ehrchen J, Varga G, Sunderkötter C, Heindel W, Roth J, Bremer C, Wall A (2009) In vivo optical imaging of cellular inflammatory response in granuloma formation using fluorescence-labeled macrophages. J Nucl Med 50(10):1676–1682
Feng L, Yang X, Shi X, Tan X, Peng R, Wang J, Liu Z (2013) Polyethylene glycol and polyethylenimine dual-functionalized nano-graphene oxide for photothermally enhanced gene delivery. Small 9(11):1989–1997
Frangioni JV (2003) In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 7(5):626–634
Gao X, Dave SR (2007) Quantum dots for cancer molecular imaging. Adv Exp Med Biol 620:57–73
Gao X, Cui Y, Levenson RM, Chung LW, Nie S (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22(8):969–976
Gao Y, Cui Y, Chan JK, Xu C (2013) Stem cell tracking with optically active nanoparticles. Am J Nucl Med Mol Imaging 3(3):232
Gioux S, Choi HS, Frangioni JV (2010) Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging 9(5):237
Giskeødegård GF, Bertilsson H, Selnæs KM, Wright AJ, Bathen TF, Viset T, Halgunset J, Angelsen A, Gribbestad IS, Tessem M-B (2013) Spermine and citrate as metabolic biomarkers for assessing prostate cancer aggressiveness. PLoS One 8(4), e62375
Harvey MD, Bablekis V, Banks PR, Skinner CD (2001) Utilization of the non-covalent fluorescent dye, NanoOrange, as a potential clinical diagnostic tool – Nanomolar human serum albumin quantitation. J Chromatogr B 754(2):345–356
Helmchen F, Denk W (2005) Deep tissue two-photon microscopy. Nat Methods 2(12):932–940
Herbáth M, Papp K, Balogh A, Matkó J, Prechl J (2014) Exploiting fluorescence for multiplex immunoassays on protein microarrays. Methods Appl Fluoresc 2(3):032001
Hielscher AH (2005) Optical tomographic imaging of small animals. Curr Opin Biotechnol 16(1):79–88
Hong H, Yang Y, Zhang Y, Cai W (2010) Non-invasive cell tracking in cancer and cancer therapy. Curr Top Med Chem 10(12):1237
Ibraheem D, Elaissari A, Fessi H (2014) Gene therapy and DNA delivery systems. Int J Pharm 459(1):70–83
Jain KK (2007) Cancer biomarkers: current issues and future directions. Curr Opin Mol Ther 9(6):563–571
Jana A, Devi KSP, Maiti TK, Singh NP (2012) Perylene-3-ylmethanol: fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release. J Am Chem Soc 134(18):7656–7659
Jokerst JV, Gambhir SS (2011) Molecular imaging with theranostic nanoparticles. Acc Chem Res 44(10):1050–1060
Kalchenko V, Neeman M, Harmelin A (2011) Whole-body imaging of hematopoietic and cancer cells using near-infrared probes. In: Advanced fluorescence reporters in chemistry and biology III. Springer Berlin Heidelberg, Springer Ser Fluoresc 10:329–346 doi:10.1007/978-3-642-18035-4
Kanekiyo Y, Tao H (2005) Selective glucose sensing utilizing complexation with fluorescent boronic acid on polycation. Chem Lett 34(2):196–197
Kartalov EP, Zhong JF, Scherer A, Quake SR, Taylor CR, Anderson WF (2006) High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques 40(1):85
Kessler MA, Meinitzer A, Petek W, Wolfbeis OS (1997) Microalbuminuria and borderline-increase albumin excretion determined with a centrifugal analyzer and the Albumin Blue 580 fluorescence assay. Clin Chem 43(6):996–1002
Kim S, Ohulchanskyy TY, Pudavar HE, Pandey RK, Prasad PN (2007) Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. J Am Chem Soc 129(9):2669–2675
Klohs J, Rudin M (2011) In vivo imaging of vascular targets using near-infrared fluorescent probes. In: Advanced fluorescence reporters in chemistry and biology III. Springer Berlin Heidelberg, Springer Ser Fluoresc 10:313-328 doi:10.1007/978-3-642-18035-4
Kumar AT, Raymond SB, Bacskai BJ, Boas DA, Georgescu R, Khismatullin D, Holt RG, Castagner JL, A’amar O, Bigio IJ (2008) Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Opt Lett 33(5):470–472
Kuramitsu Y, Nakamura K (2006) Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers. Proteomics 6(20):5650–5661
Lai J, Shah BP, Garfunkel E, Lee K-B (2013) Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release. ACS Nano 7(3):2741–2750
Lee H, Akers W, Bhushan K, Bloch S, Sudlow G, Tang R, Achilefu S (2011) Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors. Bioconjug Chem 22(4):777–784
Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Jackson EN, Marquez M, Piwnica-Worms D, Smith BD (2006) Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc 128(51):16476–16477
Liu C, Zhang P, Zhai X, Tian F, Li W, Yang J, Liu Y, Wang H, Wang W, Liu W (2012) Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence. Biomaterials 33(13):3604–3613
Maity AR, Saha A, Roy A, Jana NR (2013) Folic acid functionalized nanoprobes for fluorescence-, dark-field-, and dual-imaging-based selective detection of cancer cells and tissue. Chem Plus Chem 78(3):259–267
McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) Reporting recommendations for tumor marker prognostic studies. J Clin Oncol 23(36):9067–9072
Min Y, Li J, Liu F, Padmanabhan P, Yeow EK, Xing B (2014) Recent advance of biological molecular imaging based on lanthanide-doped upconversion-luminescent nanomaterials. Nanomaterials 4(1):129–154
Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S (2010) Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. Anal Chem 82(21):9058–9065
Mueller AJ, Freeman WR, Schaller UC, Kampik A, Folberg R (2002) Complex microcirculation patterns detected by confocal indocyanine green angiography predict time to growth of small choroidal melanocytic tumors: MuSIC Report II. Ophthalmology 109(12):2207–2214
Niemz A, Ferguson TM, Boyle DS (2011) Point-of-care nucleic acid testing for infectious diseases. Trends Biotechnol 29(5):240–250
Njiojob CN, Owens EA, Narayana L, Hyun H, Choi HS, Henary M (2015) Tailored near-infrared contrast agents for image guided surgery. J Med Chem 58(6):2845–2854
Ntziachristos V (2006) Fluorescence molecular imaging. Annu Rev Biomed Eng 8:1–33
Nurunnabi M, Khatun Z, Reeck GR, Lee DY, Y-k L (2014) Photoluminescent graphene nanoparticles for cancer photo-therapy and imaging. ACS Appl Mater Interfaces 6(15):12413–12421
Ogilby PR (2010) Singlet oxygen: there is indeed something new under the sun. Chem Soc Rev 39(8):3181–3209
Oh KJ, Cash KJ, Hugenberg V, Plaxco KW (2007) Peptide beacons: a new design for polypeptide-based optical biosensors. Bioconjug Chem 18(3):607–609
Ouellette AL, Li JJ, Cooper DE, Ricco AJ, Kovacs GT (2009) Evolving point-of-care diagnostics using up-converting phosphor bioanalytical systems. Anal Chem 81(9):3216–3221
Palacios-Rodriguez Y, Gazarian T, Rowley M, Majluf-Cruz A, Gazarian K (2007) Collection of phage-peptide probes for HIV-1 immunodominant loop-epitope. J Microbiol Methods 68(2):225–235
Pickup JC, Khan F, Zhi Z-L, Coulter J, Birch DJ (2013) Fluorescence intensity-and lifetime-based glucose sensing using glucose/galactose-binding protein. J Diabetes Sci Technol 7(1):62–71
Polom K, Murawa D, Ys R, Nowaczyk P, Hünerbein M, Murawa P (2011) Current trends and emerging future of indocyanine green usage in surgery and oncology. Cancer 117(21):4812–4822
Qiao Y, Tang H, Munske GR, Dutta P, Ivory CF, Dong W-J (2011) Enhanced fluorescence anisotropy assay for human cardiac troponin I and T detection. J Fluoresc 21(6):2101–2110
Rajagopalan R, Uetrecht P, Bugaj JE, Achilefu SA, Dorshow RB (2000) Stabilization of the optical tracer agent indocyanine green using noncovalent interactions. Photochem Photobiol 71(3):347–350
Rouhanifard SH, Nordstrøm LU, Zheng T, Wu P (2013) Chemical probing of glycans in cells and organisms. Chem Soc Rev 42(10):4284–4296
Rutten M, Janes MA, Laraway B, Gregory C, Gregory K (2010) Comparison of quantum dots and CM-DiI for labeling porcine autologous bone marrow mononuclear progenitor cells. Open Stem Cell J 2:25–36
Selvam S, Kundu K, Templeman KL, Murthy N, García AJ (2011) Minimally invasive, longitudinal monitoring of biomaterial-associated inflammation by fluorescence imaging. Biomaterials 32(31):7785–7792
Sharrna P, Brown S, Walter G, Santra S, Moudgil B (2006) Nanoparticles for bioimaging. Adv Colloid Interface Sci 123:471–485
Shephard M, Peake M, Corso O, Shephard A, Mazzachi B, Spaeth B, Barbara J, Mathew T (2010) Assessment of the Nova StatSensor whole blood point-of-care creatinine analyzer for the measurement of kidney function in screening for chronic kidney disease. Clin Chem Lab Med 48(8):1113–1119
Singh R, Mukherjee MD, Sumana G, Gupta RK, Sood S, Malhotra B (2014) Biosensors for pathogen detection: a smart approach towards clinical diagnosis. Sens Actuators B 197:385–404
Solanki A, Kim JD, Lee K-B (2008) Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging. Nanomedicine (Lond) 3(4):567–578
Stefflova K, Chen J, Zheng G (2007) Killer beacons for combined cancer imaging and therapy. Curr Med Chem 14(20):2110–2125
Steiner M-S, Duerkop A, Wolfbeis OS (2011) Optical methods for sensing glucose. Chem Soc Rev 40(9):4805–4839
Sun Y, Zhu X, Peng J, Li F (2013) Core–shell lanthanide upconversion nanophosphors as four-modal probes for tumor angiogenesis imaging. ACS Nano 7(12):11290–11300
Tan HT, Low J, Lim SG, Chung M (2009) Serum autoantibodies as biomarkers for early cancer detection. FEBS J 276(23):6880–6904
Tang L, Ren Y, Hong B, Kang KA (2006) Fluorophore-mediated, fiber-optic, multi-analyte, immunosensing system for rapid diagnosis and prognosis of cardiovascular diseases. J Biomed Opt 11(2):021011-021011-10
Tang J, Kong B, Wu H, Xu M, Wang Y, Wang Y, Zhao D, Zheng G (2013) Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging. Adv Mater 25(45):6569–6574
Tra VN, Dube DH (2014) Glycans in pathogenic bacteria–potential for targeted covalent therapeutics and imaging agents. Chem Commun 50(36):4659–4673
Tsai H-c, Doong R-a (2004) Simultaneous determination of renal clinical analytes in serum using hydrolase-and oxidase-encapsulated optical array biosensors. Anal Biochem 334(1):183–192
Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV (2013) Image-guided cancer surgery using near-infrared fluorescence. Nat Rev Clin Oncol 10(9):507–518
Valanne A, Huopalahti S, Soukka T, Vainionpaa R, Lovgren T, Harma H (2005) A sensitive adenovirus immunoassay as a model for using nanoparticle label technology in virus diagnostics. J Clin Virol 33(3):217–223
van Dam GM, Themelis G, Crane LM, Harlaar NJ, Pleijhuis RG, Kelder W, Sarantopoulos A, de Jong JS, Arts HJ, van der Zee AG (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-[alpha] targeting: first in-human results. Nat Med 17(10):1315–1319
van Scheltinga AGT, van Dam GM, Nagengast WB, Ntziachristos V, Hollema H, Herek JL, Schröder CP, Kosterink JG, Lub-de Hoog MN, de Vries EG (2011) Intraoperative near-infrared fluorescence tumor imaging with vascular endothelial growth factor and human epidermal growth factor receptor 2 targeting antibodies. J Nucl Med 52(11):1778–1785
Vasan RS (2006) Biomarkers of cardiovascular disease molecular basis and practical considerations. Circulation 113(19):2335–2362
Vashist SK (2012) Non-invasive glucose monitoring technology in diabetes management: a review. Anal Chim Acta 750:16–27
Voura EB, Jaiswal JK, Mattoussi H, Simon SM (2004) Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat Med 10(9):993–998
Wang L, Li C (2011) pH responsive fluorescence nanoprobe imaging of tumors by sensing the acidic microenvironment. J Mater Chem 21(40):15862–15871
Wang C, Sahay P (2009) Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection limits. Sensors 9(10):8230–8262
Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ (2006) Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 355(25):2631–2639
Wang L, Zhao WJ, O’Donoghue MB, Tan WH (2007) Fluorescent nanoparticles for multiplexed bacteria monitoring. Bioconjug Chem 18(2):297–301
Wang C, Cheng L, Liu Z (2011a) Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials 32(4):1110–1120
Wang C, Tao H, Cheng L, Liu Z (2011b) Near-infrared light induced < i > in vivo</i > photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 32(26):6145–6154
Wang C, Cheng L, Xu H, Liu Z (2012) Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 33(19):4872–4881
Weinstain R, Segal E, Satchi-Fainaro R, Shabat D (2010) Real-time monitoring of drug release. Chem Commun 46(4):553–555
White AG, Gray BD, Pak KY, Smith BD (2012) Deep-red fluorescent imaging probe for bacteria. Bioorg Med Chem Lett 22(8):2833–2836
Wu Y, Zhang W, Li J, Zhang Y (2013) Optical imaging of tumor microenvironment. Am J Nucl Med Mol Imaging 3(1):1
Xie J, Chen K, Huang J, Lee S, Wang J, Gao J, Li X, Chen X (2010) PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 31(11):3016–3022
Xiong L, Chen Z, Tian Q, Cao T, Xu C, Li F (2009) High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors. Anal Chem 81(21):8687–8694
Xu C, Mu L, Roes I, Miranda-Nieves D, Nahrendorf M, Ankrum JA, Zhao W, Karp JM (2011) Nanoparticle-based monitoring of cell therapy. Nanotechnology 22(49):494001
Yang Z, Zhou DM (2006) Cardiac markers and their point-of-care testing for diagnosis of acute myocardial infarction. Clin Biochem 39(8):771–780
Yang M, Li L, Jiang P, Moossa A, Penman S, Hoffman RM (2003) Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci 100(24):14259–14262
Zaheer A, Wheat TE, Frangioni JV (2002) IRDye78 conjugates for near-infrared fluorescence imaging. Mol Imaging 1(4):354–364
Zajac A, Song D, Qian W, Zhukov T (2007) Protein microarrays and quantum dot probes for early cancer detection. Colloids Surf B Biointerfaces 58(2):309–314
Zhang M, Bai L, Shang W, Xie W, Ma H, Fu Y, Fang D, Sun H, Fan L, Han M (2012) Facile synthesis of water-soluble, highly fluorescent graphene quantum dots as a robust biological label for stem cells. J Mater Chem 22(15):7461–7467
Zhang W, Peng B, Tian F, Qin W, Qian X (2013) Facile preparation of well-defined hydrophilic core–shell upconversion nanoparticles for selective cell membrane glycan labeling and cancer cell imaging. Anal Chem 86(1):482–489
Zhao X, Hilliard LR, Mechery SJ, Wang Y, Bagwe RP, Jin S, Tan W (2004) A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles. Proc Natl Acad Sci U S A 101(42):15027–15032
Zheng W, Huang P, Tu D, Ma E, Zhu H, Chen X (2015) Lanthanide-doped upconversion nano-bioprobes: electronic structures, optical properties, and biodetection. Chem Soc Rev 44(6):1379–1415
Zou P, Xu S, Povoski SP, Wang A, Johnson MA, Martin EW Jr, Subramaniam V, Xu R, Sun D (2009) Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Mol Pharm 6(2):428–440
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Demchenko, A.P. (2015). Sensing the Whole Body and Clinical Diagnostics. In: Introduction to Fluorescence Sensing. Springer, Cham. https://doi.org/10.1007/978-3-319-20780-3_14
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