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Osteoporosis

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Musculoskeletal Research and Basic Science

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Abstract

Patients with osteoporosis have high risks for vertebral and non-vertebral fractures; therefore, these patients should be adequately diagnosed and treated for prevention of fractures. It is essential to treat patients appropriately and sufficiently that the physicians must understand the mechanisms underlying osteoporosis and physiological bone homeostasis. The large population of osteoporosis is postmenopausal osteoporosis, which is categorized in primary osteoporosis. Postmenopausal osteoporosis is caused by deficiency of estrogen. Estrogen exerts its osteoprotective effects directly and indirectly to bone tissue. Also, secondary osteoporosis can be induced by various pathologic conditions, such as hyperparathyroidism, glucocorticoid treatment, and inflammatory diseases.

Clarification of the molecular basis underlying the pathophysiology of osteoporosis will open the window to develop novel therapeutic strategy for osteoporosis.

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Authors and Affiliations

  1. Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime, Japan

    Yuuki Imai MD, PhD

  2. Department of Pathophysiology, Graduate School of Medicine, Ehime University, Ehime, Japan

    Yuuki Imai MD, PhD

  3. Division of Osteoscience, Artificial Joint Integrated Center, Ehime University Hospital, Ehime University, Ehime, 791-0295, Japan

    Yuuki Imai MD, PhD

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  1. Yuuki Imai MD, PhD
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Correspondence to Yuuki Imai MD, PhD .

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Editors and Affiliations

  1. Department of Sports Medicine, Hacettepe University Medical Faculty, Ankara, Turkey

    Feza Korkusuz

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Imai, Y. (2016). Osteoporosis. In: Korkusuz, F. (eds) Musculoskeletal Research and Basic Science. Springer, Cham. https://doi.org/10.1007/978-3-319-20777-3_33

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  • DOI: https://doi.org/10.1007/978-3-319-20777-3_33

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20776-6

  • Online ISBN: 978-3-319-20777-3

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