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Role of Sphingolipids in Non-melanoma Skin Cancer

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Bioactive Sphingolipids in Cancer Biology and Therapy

Abstract

Non-melanoma skin cancer (NMSC) is the most common cancer in the world and its incidence continues to rise. NMSC includes two main types, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), both of which arise from malignant keratinocytes, the major cell type in the epidermis of the skin. Most cases of NMSC can be cured by existing new surgical techniques and chemo- or radiotherapy. However, NMSC remains a leading cause of cancer-related deaths in the United States and worldwide likely due to its extremely high incidence and recurrence rate, and limited availability of effective therapies for advanced cases. Therefore, we still need a better understanding of its pathogenesis and the development of novel and effective approaches to diagnosis, prevention, and treatment. Like many other cancers, NMSC results from dysregulation of the proliferation, differentiation, and apoptosis of cells that it originates from. Emerging evidence suggests that sphingolipids play an important role in regulating these cellular responses of keratinocytes and the homeostasis of the epidermis. In this review, we will discuss the role for sphingolipids and their metabolizing enzymes in regulating the proliferation, differentiation, and apoptosis of epidermal keratinocytes and the potential role of sphingolipids in NMSC prevention and/or therapy.

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Acknowledgement

This work was supported by National Institutes of Health Grants R01CA104834, R01CA163825, and P01CA097132 to C.M.

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Authors and Affiliations

  1. Graduate Program of Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY, USA

    Chih-Li Lin & Cungui Mao Ph.D.

  2. Department of Medicine, Stony Brook University, Stony Brook, NY, USA

    Chih-Li Lin

  3. Stony Brook University Cancer Center, T15-023, HSC, Stony Brook, NY, 11794-8155, USA

    Chih-Li Lin

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  1. Chih-Li Lin
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  2. Cungui Mao Ph.D.
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Correspondence to Cungui Mao Ph.D. .

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Editors and Affiliations

  1. Stony Brook University, Stony Brook Cancer Center, Stony Brook, New York, USA

    Yusuf A. Hannun

  2. Dept. of Physiology & Biophysics, Stony Brook University, Stony Brook, New York, USA

    Chiara Luberto

  3. Dept. of Medicine, Stony Brook University, Stony Brook, New York, USA

    Cungui Mao

  4. Dept. of Medicine, Stony Brook University, Stony Brook, New York, USA

    Lina Marie Obeid

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Lin, CL., Mao, C. (2015). Role of Sphingolipids in Non-melanoma Skin Cancer. In: Hannun, Y., Luberto, C., Mao, C., Obeid, L. (eds) Bioactive Sphingolipids in Cancer Biology and Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-20750-6_5

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