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Stem Cell and Stem Cell-Derived Molecular Therapies to Enhance Dermal Wound Healing

  • Chapter
Microscale Technologies for Cell Engineering

Abstract

Chronic wounds that do not heal with standard wound care are a growing public healthcare concern. Wound care costs associated with lower extremity ulcers, such as venous leg ulcers, pressure ulcers, and diabetic foot ulcers, place a significant burden on healthcare systems and severely lower the quality of life for patients. Advanced wound care therapies are needed to promote wound closure in recalcitrant wounds. Exogenous mesenchymal stem cell delivery and endogenous bone marrow stem cell recruitment have been investigated as advanced wound therapies, and have demonstrated promising potential for enhancing wound closure in preclinical and clinical studies. The aim of this book chapter is to review the wound healing process and pathobiology of chronic wounds, and discuss the current state of stem cell therapies as advanced wound therapies. The potential role of nano- and micro-scale technologies in addressing current limitations of stem cell therapies will also be explored.

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Abbreviations

Ang:

Angiopoietin

AV/PCL:

Aloe vera‐polycaprolactone

bFGF:

Basic fibroblast growth factor

BMP:

Bone morphogenic protein

EGF:

Epidermal growth factor

EPC:

Endothelial progenitor cell

G-CSF:

Granulocyte colony-stimulating factor

GFP:

Green fluorescent protein

GM-CSF:

Granulocyte macrophage colony-stimulating factor

HB-EGF:

Heparin-binding EGF-like growth factor

HBOT:

Hyperbaric oxygen therapy

HCT/P:

Human cells, tissues, and cellular and tissue-based product

HFSC:

Hair follicle stem cell

HGF:

Hepatocyte growth factor

HSC:

Hematopoietic stem cell

IFE:

Interfollicular epidermis

IGF:

Insulin-like growth factor

IL:

Interleukin

KGF:

Keratinocyte growth factor

Krt:

Keratin

MCP:

Monocyte chemotactic protein

MIP:

Macrophage inflammatory protein

MMP:

Matrix metalloprotease

MSC:

Mesenchymal stem cell

PDGF:

Platelet-derived growth factor

SDF:

Stromal derived factor

SMA:

Smooth muscle actin

TGF:

Transforming growth factor

TNF:

Tumor necrosis factor

VEGF:

Vascular endothelial growth factor

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  1. Department of Chemical Engineering, Queen’s University, Kingston, ON, Canada, K7L 3N6

    Jeremy A. Antonyshyn & Lindsay E. Fitzpatrick

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Antonyshyn, J.A., Fitzpatrick, L.E. (2016). Stem Cell and Stem Cell-Derived Molecular Therapies to Enhance Dermal Wound Healing. In: Singh, A., Gaharwar, A. (eds) Microscale Technologies for Cell Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-20726-1_6

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