Abstract
Developmental Bone Biology describes skeletal development as outlined by several investigational approaches including: histology at the light and electron microscopic levels; molecular biology outlining the wide array of gene and molecular controls for skeletal tissue differentiation, 3- and 4-dimensional limb bud axial differentiation and growth, and synthesis of structural macromolecules; mineralization; mechanical–biophysical effects on the developing skeleton; and radiologic parameters of growth including appearance of secondary ossification centers and times of physeal fusion.
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Shapiro, F. (2016). Developmental Bone Biology. In: Pediatric Orthopedic Deformities, Volume 1. Springer, Cham. https://doi.org/10.1007/978-3-319-20529-8_1
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