Graves’ Disease: What Is the Role and Timing of Surgery?

  • Dawn M. Elfenbein
  • Rebecca S. SippelEmail author


The surgical treatment of Graves’ disease classically was limited to a small subset of patients with contraindications to medical therapy or radioactive iodine or who presented with severe ophthalmopathy, complications of severe acute thyrotoxicosis, or concurrent thyroid nodules. With the introduction of endocrine surgery fellowship training and improving surgical outcomes, total thyroidectomy is now becoming more widely used as first-line therapy for Graves’ disease. This chapter will describe the evolving role of surgery for Graves’ disease, highlight circumstances where thyroidectomy is definitively the treatment of choice, and discuss controversies in the perioperative management of these patients.


Graves’ disease Radioactive iodine ablation Thyroidectomy Quality of life Surgical decision-making Surgical volume outcomes 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of WisconsinMadisonUSA
  2. 2.Section of Endocrine Surgery, Department of SurgeryUniversity of WisconsinMadisonUSA

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