Quantifying Structural and Functional Differences Between Normal and Fibrotic Ventricles

  • Prashanna KhwaounjooEmail author
  • Ian J. LeGrice
  • Mark L. Trew
  • Bruce H. Smaill
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)


Fibrosis is a significant component of cardiac remodeling in heart failure. However, such remodeling has not been fully quantified across a range of scales and the functional impacts on arrhythmogenesis are still poorly understood. Transmural ventricular tissue samples from WKY and SHR rats are imaged and analyzed structurally at the scale of myocardial laminae. New imaging protocols and immunohistochemical labeling are investigated for 3D reconstructions of cell distributions and interconnectivity. At larger scales, there are obvious structural differences between WKY and SHR tissue in fiber rotation and tissue connectivity. Electrical activation models show less significant differences in functional behavior between the two tissue types. Imaging extended volume 3D cell connectivity provides promising insights and will be used in the future to inform modeling at larger scales.


Cardiac remodeling Cardiomyopathy Heart failure Biophysical modelling Imaging techniques 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Prashanna Khwaounjoo
    • 1
    Email author
  • Ian J. LeGrice
    • 2
  • Mark L. Trew
    • 1
  • Bruce H. Smaill
    • 1
    • 2
  1. 1.Auckland Bioengineering InstituteThe University of AucklandAucklandNew Zealand
  2. 2.Department of PhysiologyThe University of AucklandAucklandNew Zealand

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