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Quantifying Structural and Functional Differences Between Normal and Fibrotic Ventricles

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Functional Imaging and Modeling of the Heart (FIMH 2015)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 9126))

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Abstract

Fibrosis is a significant component of cardiac remodeling in heart failure. However, such remodeling has not been fully quantified across a range of scales and the functional impacts on arrhythmogenesis are still poorly understood. Transmural ventricular tissue samples from WKY and SHR rats are imaged and analyzed structurally at the scale of myocardial laminae. New imaging protocols and immunohistochemical labeling are investigated for 3D reconstructions of cell distributions and interconnectivity. At larger scales, there are obvious structural differences between WKY and SHR tissue in fiber rotation and tissue connectivity. Electrical activation models show less significant differences in functional behavior between the two tissue types. Imaging extended volume 3D cell connectivity provides promising insights and will be used in the future to inform modeling at larger scales.

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Authors and Affiliations

  1. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

    Prashanna Khwaounjoo, Mark L. Trew & Bruce H. Smaill

  2. Department of Physiology, The University of Auckland, Auckland, New Zealand

    Ian J. LeGrice & Bruce H. Smaill

Authors
  1. Prashanna Khwaounjoo
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  2. Ian J. LeGrice
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  3. Mark L. Trew
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  4. Bruce H. Smaill
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Corresponding author

Correspondence to Prashanna Khwaounjoo .

Editor information

Editors and Affiliations

  1. Eindhoven University of Technology, Eindhoven, The Netherlands

    Hans van Assen

  2. Eindhoven University of Technology, Eindhoven, The Netherlands

    Peter Bovendeerd

  3. Maastricht University, Maastricht, The Netherlands

    Tammo Delhaas

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© 2015 Springer International Publishing Switzerland

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Khwaounjoo, P., LeGrice, I.J., Trew, M.L., Smaill, B.H. (2015). Quantifying Structural and Functional Differences Between Normal and Fibrotic Ventricles. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-20309-6_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20308-9

  • Online ISBN: 978-3-319-20309-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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