Myocardial Stiffness Estimation: A Novel Cost Function for Unique Parameter Identification

  • Anastasia NasopoulouEmail author
  • Bojan Blazevic
  • Andrew Crozier
  • Wenzhe Shi
  • Anoop Shetty
  • C. Aldo Rinaldi
  • Pablo Lamata
  • Steven A. Niederer
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)


Myocardial stiffness is a clinical biomarker used to diagnose and stratify diseases such as heart failure. This biomechanical property can be inferred from the personalisation of computational cardiac models to clinical measures. Nevertheless, previous attempts have been unable to determine a unique set of material constitutive parameters. In this study we address this shortcoming by proposing a new cost function that allows us to uncouple key parameters and uniquely describe passive material properties in patients from available clinical data.


Cardiac mechanics Myocardial stiffness Parameter estimation Myocardial characterisation Diastolic biomarkers 



The authors would like to acknowledge financial support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ NHS Foundation Trust and KCL, and support from the Wellcome Trust and EPSRC Centre of Excellence in Medical Engineering. S.A.N is supported by BHF PG/11/101/29212. PL holds a Sir Henry Dale Fellowship funded jointly by the Wellcome Trust and the Royal Society (grant no. 099973/Z/12/Z).


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Anastasia Nasopoulou
    • 1
    Email author
  • Bojan Blazevic
    • 1
  • Andrew Crozier
    • 1
  • Wenzhe Shi
    • 4
  • Anoop Shetty
    • 1
    • 3
  • C. Aldo Rinaldi
    • 1
    • 3
  • Pablo Lamata
    • 1
    • 2
  • Steven A. Niederer
    • 1
  1. 1.Division of Imaging Sciences and Biomedical EngineeringKing’s College LondonLondonUK
  2. 2.Department of Computer ScienceUniversity of OxfordOxfordUK
  3. 3.Department of CardiologyGuy’s and St. Thomas’ NHS TrustLondonUK
  4. 4.Department of ComputingImperial College LondonLondonUK

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