Abstract
Quantification of the left ventricle (LV) shape changes (remodeling) is of great importance for therapeutic management of myocardial infarction. Orthogonal shape modes derived from principal component analysis (PCA) often do not describe clinical remodeling indices. We developed a method for deriving orthogonal shape modes directly from any set of clinical indices. Cardiac magnetic resonance images of 1,991 asymptomatic volunteers from the MESA study (age 44−84, mean age 62, 52 % women) and 300 patients with myocardial infarction from the DETERMINE study (age 31−86, mean age 63, 20 % women) were obtained from the Cardiac Atlas Project. Clinical indices of LV size, sphericity, wall thickness and apical conicity were calculated. For each index, cases outside two standard deviations of the mean, but within one standard deviation for all other indices, were chosen as a representative subgroup. Orthogonal modes were defined sequentially, using the first principal component of each subgroup. At each step, the contribution of the previous mode was removed mathematically from the shape description, similar to Gram–Schmidt orthogonalization. Correlation analysis and logistic regression were performed to show the effectiveness of these features to characterize remodeling due to myocardial infarction.
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References
Sutton, M.G.S.J., Sharpe, N.: Left ventricular remodeling after myocardial infarction pathophysiology and therapy. Circulation 101, 2981–2988 (2000)
Gjesdal, O., Bluemke, D.A., Lima, J.A.: Cardiac remodeling at the population level—risk factors, screening, and outcomes. Nat. Rev. Cardiol. 8, 673–685 (2011)
Lieb, W., Gona, P., Larson, M.G., Aragam, J., Zile, M.R., Cheng, S., et al.: The natural history of left ventricular geometry in the community clinical correlates and prognostic significance of change in LV geometric pattern. JACC Cardiovasc. Imaging 7, 870–878 (2014)
Zile, M.R., Gaasch, W.H., Patel, K., Aban, I.B., Ahmed, A.: Adverse left ventricular remodeling in community-dwelling older adults predicts incident heart failure and mortality. JACC Heart Fail. 2, 512–522 (2014)
Wong, S.P., French, J.K., Lydon, A.-M., Manda, S.O.M., Gao, W., Ashton, N.G., et al.: Relation of left ventricular sphericity to 10-year survival after acute myocardial infarction. Am. J. Cardiol. 94, 1270–1275 (2004)
White, H.D., Norris, R.M., Brown, M.A., Brandt, P.W., Whitlock, R.M., Wild, C.J.: Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 76, 44–51 (1987)
Di Donato, M., Dabic, P., Castelvecchio, S., Santambrogio, C., Brankovic, J., Collarini, L., et al.: Left ventricular geometry in normal and post-anterior myocardial infarction patients: sphericity index and ‘new’ conicity index comparisons. Eur. J. Cardio-Thorac. Surg. 29, S225–S230 (2006)
Jolliffe, I.: Principal Component Analysis. Wiley Online Library, New York (2005)
Zhang, X., Cowan, B.R., Bluemke, D.A., Finn, J.P., Fonseca, C.G., Kadish, A.H., et al.: Atlas-based quantification of cardiac remodeling due to myocardial infarction. PLoS ONE 9, e110243 (2014)
McLeod, K., Caiazzo, A., Fernández, M.A., Mansi, T., Vignon-Clementel, I.E., Sermesant, M., Pennec, X., Boudjemline, Y., Gerbeau, J.-F.: Atlas-based reduced models of blood flows for fast patient-specific simulations. In: Camara, O., Pop, M., Rhode, K., Sermesant, M., Smith, N., Young, A. (eds.) STACOM 2010. LNCS, vol. 6364, pp. 95–104. Springer, Heidelberg (2010)
Bild, D.E., Bluemke, D.A., Burke, G.L., Detrano, R., Roux, A.V.D., et al.: Multi-ethnic study of atherosclerosis: objectives and design. Am. J. Epidemiol. 156, 871–881 (2002)
Kadish, A.H., Bello, D., Finn, J., Bonow, R.O., Schaechter, A., Subacius, H., et al.: Rationale and design for the defibrillators to reduce risk by magnetic resonance imaging evaluation (DETERMINE) trial. J. Cardiovasc. Electrophysiol. 20, 982–987 (2009)
Fonseca, C.G., Backhaus, M., Bluemke, D.A., Britten, R.D., Do Chung, J., Cowan, B.R.: The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart. Bioinformatics 27, 2288–2295 (2011)
Medrano-Gracia, P., Cowan, B.R., Bluemke, D.A., Finn, J., Lima, J.A., Suinesiaputra, A., Young, A.A.: Large scale left ventricular shape atlas using automated model fitting to contours. In: Ourselin, S., Rueckert, D., Smith, N. (eds.) FIMH 2013. LNCS, vol. 7945, pp. 433–441. Springer, Heidelberg (2013)
Medrano-Gracia, P., Cowan, B., Ambale-Venkatesh, B., Bluemke, D., Eng, J., Finn, J., et al.: Left ventricular shape variation in asymptomatic populations: the multi-ethnic study of atherosclerosis. J. Cardiovasc. Magn. Reson. 16, 56 (2014)
Young, A.A., Cowan, B.R., Thrupp, S.F., Hedley, W.J., Dell’Italia, L.J.: Left ventricular mass and volume: fast calculation with guide-point modeling on MR images 1. Radiology 216, 597–602 (2000)
Izumo, M., Lancellotti, P., Suzuki, K., Kou, S., Shimozato, T., Hayashi, A., et al.: Three-dimensional echocardiographic assessments of exercise-induced changes in left ventricular shape and dyssynchrony in patients with dynamic functional mitral regurgitation. Eur. J. Echocardiogr. 10, 961–967 (2009)
Hoffmann, W.: Iterative algorithms for Gram-Schmidt orthogonalization. Computing 41, 335–348 (1989)
Acknowledgements
This project was supported by award numbers R01HL087773 and R01HL121754 from the National Heart, Lung, and Blood Institute. MESA was supported by contracts N01-HC-95159 through N01-HC-95169 from the NHLBI and by grants UL1-RR-024156 and UL1-RR-025005 from NCRR. DETERMINE was supported by St. Jude Medical, Inc; and the National Heart, Lung and Blood Institute (R01HL91069). A list of participating DETERMINE investigators can be found at http://www.clinicaltrials.gov. David A. Bluemke is supported by the NIH intramural research program. Xingyu Zhang would like to gratefully acknowledge financial support from the China Scholarship Council.
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Zhang, X. et al. (2015). Orthogonal Shape Modes Describing Clinical Indices of Remodeling. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_32
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DOI: https://doi.org/10.1007/978-3-319-20309-6_32
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