A Comprehensive Framework for the Characterization of the Complete Mitral Valve Geometry for the Development of a Population-Averaged Model

  • Amir H. Khalighi
  • Andrew Drach
  • Fleur M. ter Huurne
  • Chung-Hao Lee
  • Charles Bloodworth
  • Eric L. Pierce
  • Morten O. Jensen
  • Ajit P. Yoganathan
  • Michael S. SacksEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)


Simulations of the biomechanical behavior of the Mitral Valve (MV) based on simplified geometric models are difficult to interpret due to significant intra-patient variations and pathologies in the MV geometry. Thus, it is critical to use a systematic approach to characterization and population-averaging of the patient-specific models. We introduce a multi-scale modeling framework for characterizing the entire MV apparatus geometry via a relatively small set of parameters. The leaflets and annulus are analyzed using a superquadric surface model superimposed with fine-scale filtered level-set field. Filtering of fine-scale features is performed in a spectral space to allow control of resolution, resampling and robust averaging. Chordae tendineae structure is modeled using a medial axis representation with superimposed filtered pointwise cross-sectional area field. The chordae topology is characterized using orientation and spatial distribution functions. The methodology is illustrated with the analysis of an ovine MV microtomography imaging data.


Mitral Valve Mitral Valve Regurgitation Mitral Valve Leaflet Mitral Valve Annulus Mitral Valve Apparatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Research reported in this publication was supported by National Heart, Lung, and Blood Institute of the National Institutes of Health under award number R01HL119297. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amir H. Khalighi
    • 1
  • Andrew Drach
    • 1
  • Fleur M. ter Huurne
    • 2
  • Chung-Hao Lee
    • 1
  • Charles Bloodworth
    • 3
  • Eric L. Pierce
    • 3
  • Morten O. Jensen
    • 3
  • Ajit P. Yoganathan
    • 3
  • Michael S. Sacks
    • 1
    Email author
  1. 1.The University of Texas at AustinAustinUSA
  2. 2.Eindhoven University of TechnologyEindhovenThe Netherlands
  3. 3.Georgia Institute of TechnologyAtlantaUSA

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