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International Conference on Functional Imaging and Modeling of the Heart

FIMH 2015: Functional Imaging and Modeling of the Heart pp 120–128Cite as

Sensitivity Analysis of Diffusion Tensor MRI in Simulated Rat Myocardium

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Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 9126))

Abstract

A model of cardiac microstructure and diffusion MRI is presented. The results show a good correspondence between the simulated and experimental measurements. A sensitivity analysis shows that the diffusivity has the greatest effect on both the apparent diffusion coefficient and the fractional anisotropy. The cross-sectional area of the cells is the next most important factor; the aspect ratio of the cell cross-section also affects the fractional anisotropy. Neither the cell length nor the volume fraction of cells has a marked effect.

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Acknowledgements

This work is supported by a BBSRC grant (BB/I012117/1), an EPSRC grant (EP/J013250/1) and by funding from the British Heart Foundation (BHF) Centre for Research Excellence. JES and PK are BHF Senior Basic Science Research Fellows (FS/11/50/29038; FS/12/17/29532). VG and PK are supported by BHF New Horizon Grant NH/13/30238. PK holds an ERC Advanced Grant (CardioNect). The authors acknowledge a Wellcome Trust Core Award (090532/Z/09/Z).

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Authors and Affiliations

  1. Institute of Biomedical Engineering, University of Oxford, Oxford, UK

    Joanne Bates & Vicente Grau

  2. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

    Irvin Teh & Jürgen E. Schneider

  3. Department of Computer Science, University of Oxford, Oxford, UK

    Peter Kohl

  4. National Heart and Lung Institute, Imperial College London, London, UK

    Peter Kohl

Authors
  1. Joanne Bates
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  2. Irvin Teh
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  3. Peter Kohl
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  4. Jürgen E. Schneider
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  5. Vicente Grau
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Corresponding author

Correspondence to Joanne Bates .

Editor information

Editors and Affiliations

  1. Eindhoven University of Technology, Eindhoven, The Netherlands

    Hans van Assen

  2. Eindhoven University of Technology, Eindhoven, The Netherlands

    Peter Bovendeerd

  3. Maastricht University, Maastricht, The Netherlands

    Tammo Delhaas

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© 2015 Springer International Publishing Switzerland

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Bates, J., Teh, I., Kohl, P., Schneider, J.E., Grau, V. (2015). Sensitivity Analysis of Diffusion Tensor MRI in Simulated Rat Myocardium. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-20309-6_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20308-9

  • Online ISBN: 978-3-319-20309-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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