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Assessment of Myofiber Orientation in High Resolution Phase-Contrast CT Images

  • V. BaličevićEmail author
  • S. Lončarić
  • R. Cárdenes
  • A. Gonzalez-Tendero
  • B. Paun
  • F. Crispi
  • C. Butakoff
  • B. Bijnens
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)

Abstract

Complex helical organization of cardiac fibers is one of the key factors for efficient beat-to-beat contraction and electrical impulse propagation. Complete understanding of this (inter-individual) configuration is limited by image acquisition and analysis constraints. Consequently, extensive quantification of myofiber orientation and remodeling within diverse cases is still lacking. With its high resolution and contrast, synchrotron-based phase-contrast X-ray imaging offers potential for assessing this information. Although it recently gained increased attention for biomedical purposes, only few cardiac applications were presented to this date. In this paper, we used synchrotron-based acquisitions of a healthy fetal rabbit heart and implemented a structure tensor method for estimating fiber orientation. For comparison, we generated the common rule-based model, simulating fiber angles distribution for the given geometry. Although we find similar fiber angle transmural courses compared to the theoretical, high-resolution imaging and analysis show that the myocardium in an individual is more complex than often assumed.

Keywords

Myocytes arrangement Fiber angle Synchrotron imaging Structure tensor Streeter model 

Notes

Acknowledgements

The experiments were performed on the ID19 beamline at the European Synchrotron Radiation Facility (ESRF), Grenoble, France. We are grateful to Anne Bonnin at ESRF for providing assistance in using beamline ID19. This study was partly supported by Ministry of science, education and sports of the Republic of Croatia (036-0362214-1989); Ministerio de Economia y Competitividad (SAF2012-37196, TIN2012-35874); Instituto de Salud Carlos III (PI11/00051, PI11/01709, PI12/00801,PI14/00226) integrados en el Plan Nacional de I+D+I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) Otra manera de hacer Europa; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); Obra Social la Caixa (Barcelona, Spain); Fundació Mutua Madrileña and Fundació Agrupació Mutua (Spain).

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • V. Baličević
    • 1
    Email author
  • S. Lončarić
    • 1
  • R. Cárdenes
    • 2
  • A. Gonzalez-Tendero
    • 3
    • 4
  • B. Paun
    • 2
  • F. Crispi
    • 3
    • 4
  • C. Butakoff
    • 2
  • B. Bijnens
    • 2
    • 5
  1. 1.Faculty of Electrical Engineering and ComputingUniversity of ZagrebZagrebCroatia
  2. 2.PhySenseN-RAS, Universitat Pompeu FabraBarcelonaSpain
  3. 3.Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPSUniversity of BarcelonaBarcelonaSpain
  4. 4.Centre for Biomedical Research on Rare Diseases (CIBER-ER)BarcelonaSpain
  5. 5.Institució Catalana de Recerca i Estudis Avançats (ICREA)BarcelonaSpain

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