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Solid Lipid Excipients as Matrix Agents for Sustained Drug Delivery

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Excipient Applications in Formulation Design and Drug Delivery

Abstract

Lipid excipients are attracting interest from drug developers due to their performance, ease of use, versatility and their potential to generate intellectual property through innovation in drug delivery, particularly in the case of controlled-drug release systems. Many articles have described the use of lipid excipients to develop matrix modified-release dosage forms using a range of processing techniques, therefore a comprehensive review is timely to synthesize and analyze the key information. This chapter focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and its impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions, and (iv) long term stability. Understanding the functionality of these versatile excipients in formulation is fundamental for the development of highly robust lipid-based sustained-release medicines.

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Abbreviations

API:

Active pharmaceutical ingredient

DCPD:

Dibasic calcium phosphate dihydrate

GIT:

Gastrointestinal tract

HLB:

Hydrophilic-lipophilic balance

HME:

Hot melt extrusion

HPC:

Hydroxypropyl cellulose

HPMC:

Hydroxypropyl methyl cellulose

MCC:

Microcrystalline cellulose

MFT:

Minimum film forming temperature

NLC:

Nanostructured lipid carrier

PEG:

Polyethylene glycol

PVP:

Poly(vinylpyrrolidone)

SLN:

Solid lipid nanoparticles

SR:

Sustained release

Tg:

Glass-liquid transition temperature

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Declaration of interests

All authors are employed by Gattefosse SAS, the company that produces and commercializes Compritol® 888 ATO, Precirol® ATO 5 and the Gelucire® product brand. Editorial assistance for this manuscript, funded by Gattefosse SAS, was provided by Margaret Haugh, MediCom Consult.

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Authors and Affiliations

  1. Gattefossé S.A.S., 36 chemin de Genas—CS 70070, 69804, Saint-Priest cedex, France

    Yvonne Rosiaux, Vincent Jannin, Sophie Hughes & Delphine Marchaud

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  1. Yvonne Rosiaux
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  2. Vincent Jannin
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  3. Sophie Hughes
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  4. Delphine Marchaud
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Correspondence to Yvonne Rosiaux .

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Editors and Affiliations

  1. Bristol-Myers Squibb, Co., New Brunswick, New Jersey, USA

    Ajit S Narang

  2. Division of Industrial Pharmacy, Department of Pharmacy Practice, The University of Toledo, TOLEDO, Ohio, USA

    Sai H S. Boddu

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Rosiaux, Y., Jannin, V., Hughes, S., Marchaud, D. (2015). Solid Lipid Excipients as Matrix Agents for Sustained Drug Delivery. In: Narang, A., Boddu, S. (eds) Excipient Applications in Formulation Design and Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-20206-8_9

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