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Excipients and Non-medicinal Agents as Active Pharmaceutical Ingredients

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Excipient Applications in Formulation Design and Drug Delivery

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Abstract

“Atypical Actives” are a class of excipients that serve as Active Pharmaceutical Ingredients (APIs) in over-the-counter (OTC) medications. Atypical actives are present in a variety of dosage forms administered through oral, topical, parenteral and ophthalmic routes. Most atypical actives are derived from a natural source and hence pose fewer side effects compared to prescription medications. In spite of the advantages associated with the use of atypical actives, they have never shared the spotlight with APIs and are continuously disregarded or ignored. This chapter intends to highlight atypical actives and non-medicinal agents in OTC drug products with an emphasis on their therapeutic properties.

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Authors and Affiliations

  1. Department of Pharmacy Practice, The University of Toledo Health Science Campus, 3000 Arlington Ave, 43614, Toledo, OH, USA

    Sai HS. Boddu, Alan Rega & Kenneth Alexander

  2. Department of Pharmaceutical Sciences, South College School of Pharmacy, Knoxville, TN, USA

    Jwala Renukuntla

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  1. Sai HS. Boddu
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  2. Jwala Renukuntla
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  3. Alan Rega
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  4. Kenneth Alexander
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Editors and Affiliations

  1. Bristol-Myers Squibb, Co., New Brunswick, New Jersey, USA

    Ajit S Narang

  2. Division of Industrial Pharmacy, Department of Pharmacy Practice, The University of Toledo, TOLEDO, Ohio, USA

    Sai H S. Boddu

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© 2015 Springer International Publishing Switzerland

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Boddu, S., Renukuntla, J., Rega, A., Alexander, K. (2015). Excipients and Non-medicinal Agents as Active Pharmaceutical Ingredients. In: Narang, A., Boddu, S. (eds) Excipient Applications in Formulation Design and Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-20206-8_21

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