Abstract
Liver response to injury includes a relatively narrow spectrum of morphologic changes, and accordingly there are only several pathologic patterns that can be recognized microscopically. First of all one must determine if the liver biopsy is from a native liver or from a liver transplant. If it is native liver one must decide if the liver was biopsied for a mass lesion requiring a tumor diagnosis or a diffuse liver disease. Relevant patient data provided by the clinician is always welcome and encouraged to provide appropriate contextual review. First, diffue liver disease should be divided into acute and chronic liver disease. Next, the liver is classified according the predominent pattern of injury. Then, after incorporation of clinical information and laboratory data, a differential diagnosis can be rendered.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunt EM, Tiniakos DG. Fatty liver disease. In: Odze RD, Goldblum JR, editors. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2015. p. 1329–55.
Burt A, Portman B, Ferrell L, editors. MacSween’s pathology of the liver. 6th ed. Edinburgh: Churchill Livingstone, Elsevier; 2012.
Desmet VJ, Rosai J. Liver. In: Rosai J, editor. Rosai and Ackerman’s surgical pathology. 10th ed. Elsevier Mosby: Edinburgh; 2011. p. 857–980.
Geller SA, Petrovic LM. Biopsy interpretation of the liver. 2nd ed. Philadelphia, PA: Wolters Kluwer Health; 2009.
Kanel GC, Korula J. Atlas of liver pathology. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2005.
Lefkowitch JH. Scheuer’s liver biopsy interpretation. 8th ed. Philadelphia, PA: Saunders, Elsevier; 2010.
Ludwig J. Practical liver biopsy interpretation. Diagnostic algorithms. Chicago, IL: American Society of Clinical Pathologists; 1992.
Suriawinata AA, Thung SN. Liver pathology. An atlas and concise guide. New York, NY: Demos Medical; 2011.
Theise ND, Saxena R. Algorithmic approach to diagnosis of liver diseases. In: Odze RD, Goldblum JR, editors. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2015. p. 1143–69.
Torbenson M. Biopsy interpretation of the liver. Philadelphia, PA: Wolters Kluwer Health; 2015.
Yeh MM, Crawford JM. Vascular disorders of the liver. In: Odze RD, Goldblum JR, editors. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2015. p. 1384–407.
Brunt EM, Gouw AS, Hubscher SG, et al. Pathology of the liver sinusoids. Histopathology. 2014;64:907–20.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
O’Neil, M., Damjanov, I., Taylor, R.M. (2015). Patterns of Liver Injury. In: Liver Pathology for Clinicians. Pathology for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-319-20080-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-20080-4_5
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-20079-8
Online ISBN: 978-3-319-20080-4
eBook Packages: MedicineMedicine (R0)