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Principles and Approaches in Surgical Resection of Esophageal Cancer

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Abstract

Despite the scarcity of level I evidence, many strongly held opinions persist regarding best practices for the surgical management of esophageal and gastroesophageal junction tumors. The range of opinions span from a seeming nihilism, wherein the role of esophagectomy is considered to be primarily palliative, to a belief in “radical” resections, wherein an en bloc esophagectomy constitutes the major component of a curative treatment strategy. Fortunately, some data have accrued during the past decade that can help clarify at least some of the principle areas of importance in esophageal resection. This new knowledge includes clarification of the variable risks of developing nodal disease, on the basis of tumor stage, and what role the assessed risk should play in the choice of operation, the importance of operative margins, and the oncologic implications of technical complications.

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References

  1. Rizk N, Bach P, Schrag D, et al. The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma. J Am Coll Surg. 2004;98(1):42–50.

    Article  Google Scholar 

  2. Hulscher JB, Tijssen JG, Obertop H, van Lanschot JJ. Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis. Ann Thorac Surg. 2001;72(1):306–13.

    Article  CAS  PubMed  Google Scholar 

  3. Hulscher JB, van Sandick JW, De Boer AG, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 2002;347(21):1662–9.

    Article  PubMed  Google Scholar 

  4. Ayantunde AA, Ng MY, Pal S, Welch NT, Parsons SL. Analysis of blood transfusion predictors in patients undergoing elective oesophagectomy for cancer. BMC Surg. 2008;8:3.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Mitchell JD. Anastomotic leak after esophagectomy. Thorac Surg Clin. 2006;16(1):1–9.

    Article  PubMed  Google Scholar 

  6. Rizzetto C, DeMeester SR, Hagen JA, Peyre CG, Lipham JC, DeMeester TR. En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2008;135(6):1228–36.

    Article  CAS  PubMed  Google Scholar 

  7. Altorki N, Kent M, Ferrara C, Port J. Three-field node dissection for squamous cell and adenocarcinoma of the esophagus. Ann Surg. 2002;236(2):177–83.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Glyn J, Lamb PJ, Thompson SK. The role of lymphadenectomy in esophageal cancer. Ann Surg. 2009;250(20):206–9.

    Google Scholar 

  9. Nishihara T, Hirayama K, Mori S. A prospective randomized trial of extended cervical and superior mediastinal lymphadenectomy for carcinoma of the thoracic esophagus. Am J Surg. 1998;175:47–51.

    Article  Google Scholar 

  10. Schwarz RE, Smith DD. Clinical impact of lymphadenectomy extent in resectable esophageal cancer. J Gastrointest Surg. 2007;11(11):1384–93; discussion 93–4.

    Article  PubMed  Google Scholar 

  11. Peyre CG, Hagen JA, DeMeester SR, et al. The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. Ann Surg. 2008;248(4):549–56.

    PubMed  Google Scholar 

  12. Rizk NP, Ishwaran H, Rice TW, et al. Optimum lymphadenectomy for esophageal cancer. Ann Surg. 2010;251(1):46–50.

    Article  PubMed  Google Scholar 

  13. Rizk N, Venkatraman E, Park B, Flores R, Bains MS, Rusch V, American Joint Committee on Cancer staging system. The prognostic importance of the number of involved lymph nodes in esophageal cancer: implications for revisions of the American Joint Committee on Cancer staging system. J Thorac Cardiovasc Surg. 2006;132(6):1374–81.

    Article  PubMed  Google Scholar 

  14. Nishihira T, Hirayama K, Mori S. A prospective randomized trial of extended cervical and superior mediastinal lymphadenectomy for carcinoma of the thoracic esophagus. Am J Surg. 1998;175(1):47–51.

    Article  CAS  PubMed  Google Scholar 

  15. Omloo JM, Lagarde SM, Hulscher JB, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007;246(6):992–1000; discussion 1000–1.

    Article  PubMed  Google Scholar 

  16. Kim SH, Karpeh MS, Klimstra DS, Leung D, Brennan MF. Effect of microscopic resection line disease on gastric cancer survival. J Gastrointest Surg. 1999;3(1):24–33.

    Article  CAS  PubMed  Google Scholar 

  17. Burrow WM. Gastrointestinal function and related problems following esophagectomy. Semin Thorac Cardiovasc Surg. 2004;16(2):142–51.

    Article  Google Scholar 

  18. Fok M, Cheng SW, Wong J. Pyloroplasty versus no drainage in gastric replacement of the esophagus. Am J Surg. 1991;162:447–52.

    Article  CAS  PubMed  Google Scholar 

  19. Nguyen NT, Dholakia C, Nguyen XM, Revis K. Outcomes of minimally invasive esophagectomy without pyloroplasty: analysis of 109 cases. Am Surg. 2010;76(10):1135–8.

    PubMed  Google Scholar 

  20. Lerut TE, van Lanschot JJ. Chronic symptoms after subtotal or partial oesophagectomy: diagnosis and treatment. Best Pract Res Clin Gastroenteol. 2004;18(5):901–15.

    Article  CAS  Google Scholar 

  21. Luketich JD, Pennathur A, Awais O, et al. Outcomes after minimally invasive esophagectomy: review of over 1000 patients. Ann Surg. 2012;256(1):95–103.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Cerfolio RJ, Bryant AS, Cannon CI, et al. Is botulinum toxin injection of the pylorus during Ivor Lewis esophagogastrectomy the optimal drainage strategy? J Thorac Cardiovasc Surg. 2009;137:565–72.

    Article  PubMed  Google Scholar 

  23. Eldaif SM, Lee R, Adams KN, et al. Intrapyloric botulinum injection increases postoperative esophagectomy complications. Ann Thorac Surg. 2014;97:1959–65.

    Article  PubMed  Google Scholar 

  24. Hwanson EW, Swanson SJ, Swanson RS. Endoscopic pyloric balloon dilation obviates the need for pyloroplasty at esophagectomy. Surg Endosc. 2012;26:2023–8.

    Article  Google Scholar 

  25. Lanuti M, deDelva P, Morse CR, et al. Management of delayed gastric emptying after esophagectomy with endoscopic balloon dilatation of the pylorus. Ann Thorac Surg. 2011;91:1019–24.

    Article  PubMed  Google Scholar 

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Correspondence to Nabil Pierre Rizk MD .

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Rizk, N.P. (2015). Principles and Approaches in Surgical Resection of Esophageal Cancer. In: Saba, N., El-Rayes, B. (eds) Esophageal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-20068-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-20068-2_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20067-5

  • Online ISBN: 978-3-319-20068-2

  • eBook Packages: MedicineMedicine (R0)

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