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Cellular and Molecular Biology of Esophageal Cancer

  • Chapter
Esophageal Cancer

Abstract

Esophageal cancers comprise cancers of different histological types with diverse cellular and molecular bases. The major histological types of esophageal cancers are squamous cell carcinoma and adenocarcinoma. It is important to note that there are histological variants of squamous cell carcinoma and adenocarcinoma such as basaloid squamous cell carcinoma, spindle cell carcinoma, mucoepidermoid carcinoma, and adenosquamous carcinoma. In addition, neuroendocrine neoplasms such as small cell carcinoma of the esophagus account for approximately 1 % of primary esophageal carcinoma. All these carcinomas have distinct clinicopathological features. Limited studies have revealed that the cellular and molecular biology of these uncommon types of esophageal carcinomas are different from those of esophageal squamous cell carcinoma or adenocarcinoma.

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Authors and Affiliations

  1. Menzies Health Institute Queensland, Griffith University and Pathology Queensland, Gold Coast University Hospital, Gold Coast, QLD, Australia

    Alfred King-yin Lam MBBS, MD, PhD, FRCPA

  2. School of Medicine, Griffith University, Gold Coast, QLD, Q 4222, Australia

    Alfred King-yin Lam MBBS, MD, PhD, FRCPA

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  1. Alfred King-yin Lam MBBS, MD, PhD, FRCPA
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Correspondence to Alfred King-yin Lam MBBS, MD, PhD, FRCPA .

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  1. Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USA

    Nabil F. Saba

  2. Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USA

    Bassel F. El-Rayes

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Lam, A.Ky. (2015). Cellular and Molecular Biology of Esophageal Cancer. In: Saba, N., El-Rayes, B. (eds) Esophageal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-20068-2_2

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