Abstract
The advent of large of multi-modal imaging databases opens up the opportunity to learn how local intensity patterns covariate between multiple modalities. These models can then be used to describe expected intensities in an unseen image modalities given one or multiple observations, or to detect deviations (e.g. pathology) from the expected intensity patterns. In this work, we propose a template-based multi-modal generative mixture-model of imaging data and apply it to the problems of inlier/outlier pattern classification and image synthesis. Results on synthetic and patient data demonstrate that the proposed method is able to synthesise unseen data and accurately localise pathological regions, even in the presence of large abnormalities. It also demonstrates that the proposed model can provide accurate and uncertainty-aware intensity estimates of expected imaging patterns.
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Acknowledgments
MJC receives funding from EPSRC (EP/H046410/1). MM and CS are supported by the UCL Leonard Wolfson Experimental Neurology Centre (PR/ylr/18575). SO receives funding from the EPSRC (EP/H046410/1, EP/J020990/1, EP/K005278), the MRC (MR/J01107X/1), the EU-FP7 project VPH-DARE@IT (FP7-ICT-2011-9-601055), the NIHR Biomedical Research Unit (Dementia) at UCL and the National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative - BW.mn.BRC10269).
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Cardoso, M.J., Sudre, C.H., Modat, M., Ourselin, S. (2015). Template-Based Multimodal Joint Generative Model of Brain Data. In: Ourselin, S., Alexander, D., Westin, CF., Cardoso, M. (eds) Information Processing in Medical Imaging. IPMI 2015. Lecture Notes in Computer Science(), vol 9123. Springer, Cham. https://doi.org/10.1007/978-3-319-19992-4_2
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DOI: https://doi.org/10.1007/978-3-319-19992-4_2
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