Abstract
Intestinal tumorigenesis is characterized by accumulation of genetic and epigenetic alterations that lead to enhanced malignant potential of epithelial cells. Recent evidence suggests that 18–22 nt small non-coding RNAs, microRNAs (miRNAs) play a crucial role in epigenetic regulation during carcinogenesis. Regulating hundreds of targets simultaneously, miRNAs can affect multiple signaling pathways and serve as a “hub” in gene regulatory network. A large part of oncogenes and tumor suppressors are controlled by miRNAs, and conversely, these genes regulate miRNA expression by transcriptional control and by interfering with the miRNA biogenesis process. In addition, somatic mutations and single nucleotide polymorphisms in miRNA genes and in target messenger RNAs attenuate miRNA-mediated gene suppression efficiency. These complicated gene–miRNA interactions create aberrant gene expression profiles, which lead to disruption of cellular homeostasis and eventually to carcinogenesis. In this chapter, we summarize a variety of dysregulation mechanisms of miRNAs and present an overview of miRNA involvement in intestinal tumorigenesis, mainly in colorectal cancer.
Keywords
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Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215–233. doi:10.1016/j.cell.2009.01.002
Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP (2008) The impact of microRNAs on protein output. Nature 455(7209):64–71. doi:10.1038/nature07242
Ozsolak F, Poling LL, Wang Z, Liu H, Liu XS, Roeder RG et al (2008) Chromatin structure analyses identify miRNA promoters. Genes Dev 22(22):3172–3183. doi:10.1101/gad.1706508
Godnic I, Zorc M, Jevsinek Skok D, Calin GA, Horvat S, Dovc P et al (2013) Genome-wide and species-wide in silico screening for intragenic microRNAs in human, mouse and chicken. PLoS ONE 8(6):e65165. doi:10.1371/journal.pone.0065165
Lutter D, Marr C, Krumsiek J, Lang EW, Theis FJ (2010) Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics 11:224. doi:10.1186/1471-2164-11-224
Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I et al (2008) E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13(3):272–286. doi:10.1016/j.ccr.2008.02.013
Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genetics 11(9):597–610. doi:10.1038/nrg2843
Suzuki HI, Miyazono K (2011) Emerging complexity of microRNA generation cascades. J Biochem 149(1):15–25. doi:10.1093/jb/mvq113
Spizzo R, Nicoloso MS, Croce CM, Calin GA (2009) SnapShot: microRNAs in cancer. Cell 137(3):586–586, e1. doi:10.1016/j.cell.2009.04.040
Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101(9):2999–3004. doi:10.1073/pnas.0307323101
Mathelier A, Carbone A (2013) Large scale chromosomal mapping of human microRNA structural clusters. Nucl Acids Res 41(8):4392–4408. doi:10.1093/nar/gkt112
Liang Y, Ridzon D, Wong L, Chen C (2007) Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8:166. doi:10.1186/1471-2164-8-166
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al (2005) MicroRNA expression profiles classify human cancers. Nature 435(7043):834–838. doi:10.1038/nature03702
Petrocca F, Vecchione A, Croce CM (2008) Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res 68(20):8191–8194. doi:10.1158/0008-5472.CAN-08-1768
Kent OA, Fox-Talbot K, Halushka MK (2013) RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets Oncogene 32(20):2576–2585. doi:10.1038/onc.2012.266
Hermeking H (2012) MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer 12(9):613–626. doi:10.1038/nrc3318
Chang T-C, Zeitels LR, Hwang H-W, Chivukula RR, Wentzel EA, Dews M et al (2009) Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A 106(9):3384–3389. doi:10.1073/pnas.0808300106
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A et al (2005) RAS is regulated by the let-7 microRNA family. Cell 120(5):635–647. doi:10.1016/j.cell.2005.01.014
Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE et al (2005) A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. New Eng J Med 353(17):1793–1801. doi:10.1056/NEJMoa050995
Ofir M, Hacohen D, Ginsberg D (2011) MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res 9(4):440–447. doi:10.1158/1541-7786.MCR-10-0344
Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setién F et al (2007) Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 67(4):1424–1429. doi:10.1158/0008-5472.CAN-06-4218
Liu Y, Zhou Y, Feng X, An P, Quan X, Wang H et al (2014) MicroRNA-126 functions as a tumor suppressor in colorectal cancer cells by targeting CXCR4 via the AKT and ERK1/2 signaling pathways. Int J Oncol 44(1):203–210. doi:10.3892/ijo.2013.2168
Zhang Y, Wang X, Xu B, Wang B, Wang Z, Liang Y et al (2013) Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. Oncol Rep 30(4):1976–1984. doi:10.3892/or.2013.2633
Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR, Goel A (2010) Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res 70(16):6609–6618. doi:10.1158/0008-5472.CAN-10-0622
Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q et al (2011) miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int J Cancer 128(6):1269–1279. doi:10.1002/ijc.25452
Pagliuca A, Valvo C, Fabrizi E, di Martino S, Biffoni M, Runci D et al (2013) Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression. Oncogene 32(40):4806–4813. doi:10.1038/onc.2012.495
Goel A, Boland CR (2012) Epigenetics of colorectal cancer. Gastroenterology 143(6):1442–1460, e1. doi:10.1053/j.gastro.2012.09.032
Pichiorri F, Suh S-S, Rocci A, De Luca L, Taccioli C, Santhanam R et al (2010) Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 18(4):367–381
Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G et al (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10(5):593–601. doi:10.1038/ncb1722
Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim Y-H, Tsuchiya KD et al (2008) Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 27(27):3880–3888. doi:10.1038/onc.2008.10
Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R et al (2011) MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis 32(7):1033–1042. doi:10.1093/carcin/bgr081
Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY et al (2013) MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene 32(15):1910–1920. doi:10.1038/onc.2012.214
Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449(7163):682–688. doi:10.1038/nature06174
Nishida N, Yamashita S, Mimori K, Sudo T, Tanaka F, Shibata K et al (2012) MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells. Ann Surg Oncol. doi:10.1245/s10434-012-2246-1
Inui M, Martello G, Piccolo S (2010) MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11(4):252–263. doi:10.1038/nrm2868
Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N et al (2008) MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299(4):425–436. doi:10.1001/jama.299.4.425
Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E et al (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 104(40):15805–15810. doi:10.1073/pnas.0707628104
Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y et al (2010) MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem 285(28):21496–21507. doi:10.1074/jbc.M109.083337
Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink, JAF, Bolijn A et al (2008) Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 68(14):5795–5802. doi:10.1158/0008-5472.CAN-08-0951
Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S et al (2012) Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood 119(10):2314–2324. doi:10.1182/blood-2011-10-386235
Naguibneva I, Ameyar-Zazoua M, Polesskaya A, Ait-Si-Ali S, Groisman R, Souidi M et al (2006) The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol 8(3):278–284. doi:10.1038/ncb1373
Ota T, Doi K, Fujimoto T, Tanaka Y, Ogawa M, Matsuzaki H et al (2012) KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells. Anticancer Res 32(6):2271–2275.
Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K et al (2008) miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 7(2):255–264
Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK et al (2009) Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 35(6):856–867. doi:10.1016/j.molcel.2009.09.006
Kelly TJ, Souza AL, Clish CB, Puigserver P (2011) A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol 31(13):2696–2706. doi:10.1128/MCB.01242-10
Medina R, Zaidi SK, Liu C-G, Stein JL, van Wijnen AJ, Croce CM, Stein GS (2008) MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res 68(8):2773–2780. doi:10.1158/0008-5472.CAN-07-6754
Jia CY, Li HH, Zhu XC, Dong YW, Fu D, Zhao QL et al (2011) MiR-223 suppresses cell proliferation by targeting IGF-1R. PLoS ONE 6(11):e27008. doi:10.1371/journal.pone.0027008
Wu L, Li H, Jia CY, Cheng W, Yu M, Peng M et al (2012) MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett 586(7):1038–1043. doi:10.1016/j.febslet.2012.02.050
Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R et al (2011) Genome-wide profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer. Cancer Res 71(17):5646–5658. doi:10.1158/0008-5472.CAN-11-1076
Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T (2008) Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68(11):4123–4132. doi:10.1158/0008-5472.CAN-08-0325
Bandres E, Agirre X, Bitarte N, Ramirez N, Zarate R, Roman-Gomez J et al (2009) Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 125(11):2737–2743. doi:10.1002/ijc.24638
Suzuki H, Maruyama R, Yamamoto E, Kai M (2013) Epigenetic alteration and microRNA dysregulation in cancer. Front Genet 4(December):258. doi:10.3389/fgene.2013.00258
Fabbri M, Calin GA (2010) Epigenetics and miRNAs in human cancer. Adv Genet 70:87–99 (1st ed, Elsevier Inc.). doi:10.1016/B978-0-12-380866-0.60004-6
Ryan BM, Robles AI, Harris CC (2010) Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer 10(6):389–402. doi:10.1038/nrc2867
Yang R, Schlehe B, Hemminki K, Sutter C, Bugert P, Wappenschmidt B et al (2010) A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Res Treat 121(3):693–702. doi:10.1007/s10549-009-0633-5
Zhang W, Winder T, Ning Y, Pohl A, Yang D, Kahn M et al (2011) A let-7 microRNA-binding site polymorphism in 3†²-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy. Annal Oncol 22(1):104–109. doi:10.1093/annonc/mdq315
Pan X-M, Sun R-F, Li Z-H, Guo X-M, Zhang Z, Qin H-J et al (2014) A let-7 KRAS rs712 polymorphism increases colorectal cancer risk. Tumour Biol 35(1):831–835. doi:10.1007/s13277-013-1114-3
Landi D, Gemignani F, Naccarati A, Pardini B, Vodicka P, Vodickova L et al (2008) Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis 29(3):579–584. doi:10.1093/carcin/bgm304
Lee LW, Zhang S, Etheridge A, Ma L, Martin D, Galas D, Wang K (2010) Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA 16(11):2170–2180. doi:10.1261/rna.2225110
Chang H-T, Li S-C, Ho M-R, Pan H-W, Ger L-P, Hu L-Y et al (2012) Comprehensive analysis of microRNAs in breast cancer. BMC Genomics 13(Suppl 7):S18. doi:10.1186/1471-2164-13-S7-S18
Li S-C, Liao Y-L, Ho M-R, Tsai K-W, Lai C-H, Lin W (2012) miRNA arm selection and isomiR distribution in gastric cancer. BMC Genomics 13(Suppl 1):S13. doi:10.1186/1471-2164-13-S1-S13
Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39(5):673–677. doi:10.1038/ng2003
Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA et al (2009) A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 41(3):365–370. doi:10.1038/ng317
Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R et al (2010) A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18(4):303–315. doi:10.1016/j.ccr.2010.09.007
Iliou MS, da Silva-Diz V, Carmona FJ, Ramalho-Carvalho J, Heyn H, Villanueva A et al (2013) Impaired DICER1 function promotes stemness and metastasis in colon cancer. Oncogene (August):1–13. doi:10.1038/onc.2013.398
Faber C, Horst D, Hlubek F, Kirchner T (2011) Overexpression of Dicer predicts poor survival in colorectal cancer. Eur J Cancer 47(9):1414–1419. doi:10.1016/j.ejca.2011.01.006
Papachristou DJ, Korpetinou A, Giannopoulou E, Antonacopoulou AG, Papadaki H, Grivas P et al (2011) Expression of the ribonucleases drosha, dicer, and ago2 in colorectal carcinomas virchows archiv. Int J Pathol 459(4):431–440. doi:10.1007/s00428-011-1119-5
Stratmann J, Wang C-J, Gnosa S, Wallin A, Hinselwood D, Sun X-F, Zhang H (2011) Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. BMC Cancer 11(1):345. doi:10.1186/1471-2407-11-345
Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim S-O et al (2013) EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497(7449):383–387. doi:10.1038/nature12080
Paroo Z, Ye X, Chen S, Liu Q (2009) Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell 139(1):112–122. doi:10.1016/j.cell.2009.06.044
Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K (2009) Modulation of microRNA processing by p53. Nature 460(7254):529–533. doi:10.1038/nature08199
Michlewski G, Guil S, Semple CA, Cáceres JF (2008) Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell 32(3):383–393. doi:10.1016/j.molcel.2008.10.013
Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Ramos A, Gherzi R, Rosenfeld MG (2009) The RNA-binding protein ksrp promotes the biogenesis of a subset of miRNAs. Nature 459(7249):1010–1014. doi:10.1038/nature08025.The
Viswanathan SR, Daley GQ, Gregory RI (2008) Selective blockade of microRNA processing by Lin28. Science 320(5872):97–100. doi:10.1126/science.1154040
Piskounova E, Polytarchou C, Thornton JE, Hagan JP, Lapierre J, Pothoulakis C et al (2012) Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 147(5):730–748. doi:10.1016/j.cell.2011.10.039. Oncogenic
Rinn JL, Chang HY (2012) Genome regulation by long noncoding RNAs. Annu Rev Biochem 81:145–166. doi:10.1146/annurev-biochem-051410-092902
Calin GA, Liu C, Ferracin M, Hyslop T, Spizzo R, Sevignani C et al (2007) Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12(3):215–229. doi:10.1016/j.ccr.2007.07.027
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J (2013) Natural RNA circles function as efficient microRNA sponges. Nature 495(7441):384–388. doi:10.1038/nature11993
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A et al (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495(7441):333–338. doi:10.1038/nature11928
Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L et al (2013) Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell 25(1):69–80. doi:10.1016/j.devcel.2013.03.002
De Giorgio A, Krell J, Harding V, Stebbing J, Castellano L (2013) Emerging roles of ceRNAs in cancer: insights from the regulation of PTEN. Mol Cell Biol. doi:10.1128/MCB.00683-13
Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U et al (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147(2):344–357. doi:10.1016/j.cell.2011.09.029
Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer Nat Rev Cancer 8(5):387–398. doi:10.1038/nrc2389
Muzny DM, Bainbridge MN, Chang K, Dinh HH, Drummond JA, Fowler G et al (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330–337. doi:10.1038/nature11252
Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5):759–767
Kim NH, Cha YH, Kang SE, Lee Y, Lee I, Cha SY et al (2013) p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle 12(10):1578–1587. doi:10.4161/cc.24739
Mongroo PS, Rustgi AK (2010) The role of the miR-200 family in epithelial-mesenchymal transition. Cancer Biol Ther 10(3):219–222
Yu C-C, Tsai L-L, Wang M-L, Yu C-H, Lo W-L, Chang Y-C et al (2013) miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer. Cancer Res 73(11):3425–3440. doi:10.1158/0008-5472.CAN-12-3840
Rani SB, Rathod SS, Karthik S, Kaur N, Muzumdar D, Shiras AS (2013) MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro Oncol 15(10):1302–1316. doi:10.1093/neuonc/not090
Dynoodt P, Speeckaert R, De Wever O, Chevolet I, Brochez L, Lambert J, Van Gele M (2013) miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells. Int J Oncol 42(4):1443–1451. doi:10.3892/ijo.2013.1823
Mogilyansky E, Rigoutsos I (2013) The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Different 20(12):1603–1614. doi:10.1038/cdd.2013.125
Pao W, Chmielecki J (2010) Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer 10(11):760–774. doi:10.1038/nrc2947
Mlcochova J, Faltejskova P (2013) MicroRNAs targeting EGFR signalling pathway in colorectal cancer. J Cancer Res Clin Oncol 1615–1624. doi:10.1007/s00432-013-1470-9
Guo C, Sah JF, Beard L, Willson JKV, Markowitz SD, Guda K (2008) The Noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosome Cancer 946(April):939–946. doi:10.1002/gcc
Mestdagh P, Boström A-K, Impens F, Fredlund E, Van Peer G, De Antonellis P et al (2010) The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell 40(5):762–773. doi:10.1016/j.molcel.2010.11.038
Li Q, Zhang D, Wang Y, Sun P, Hou X, Larner J et al (2013) MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation. Sci Rep 3:2038. doi:10.1038/srep02038
Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J et al (2013) MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut 62(9):1315–1326. doi:10.1136/gutjnl-2011-301846
Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F, Esteller M (2012) Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 31(16):2062–2074. doi:10.1038/onc.2011.383
Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68(19):7846–7854. doi:10.1158/0008-5472.CAN-08-1942
He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y et al (2007) A microRNA component of the p53 tumour suppressor network. Nature 447(7148):1130–1134. doi:10.1038/nature05939
Yamakuchi M, Ferlito M, Lowenstein CJ (2008) miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A 105(36):13421–13426. doi:10.1073/pnas.0801613105
Braun CJ, Zhang X, Savelyeva I, Wolff S, Moll UM, Schepeler T et al. (2008) p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res 68(24):10094–10104. doi:10.1158/0008-5472.CAN-08-1569
Nishida N, Yokobori T, Mimori K, Sudo T, Tanaka F, Shibata K et al (2011) MicroRNA miR-125b is a prognostic marker in human colorectal cancer. Int J Oncol 38(5):1437–1443. doi:10.3892/ijo.2011.969
Chang C-J, Chao C-H, Xia W, Yang J-Y, Xiong Y, Li C-W et al (2011) p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 13(3):317–323. doi:10.1038/ncb2173
Siemens H, Jackstadt R, Hünten S, Kaller M, Menssen A, Götz U, Hermeking H (2011) miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10(24):4256–4271. doi:10.4161/cc.10.24.18552
Garzon R, Marcucci G, Croce CM (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 9(10):775–789. doi:10.1038/nrd3179
Schwarzenbach H, Nishida N, Calin GA, Pantel K (2014) Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. doi:10.1038/nrclinonc.2014.5
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Nishida, N., Calin, G. (2015). MicroRNA Involvement in Intestinal Tumorigenesis. In: Yang, V., Bialkowska, A. (eds) Intestinal Tumorigenesis. Springer, Cham. https://doi.org/10.1007/978-3-319-19986-3_6
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