Abstract
Probiotics are live microorganisms which when administered in adequate amounts confer beneficial health benefits to the host. However, commonly consumed medical drugs may interact with probiotic bacteria and influence their viability and functionality. The objective of this study was to determine the impact of commonly administered medical drugs on the survival of Bifidobacterium. Five strains of Bifidobacterium (B. breve, B. longum, B. infantis, B. adolescentis, and B. bifidium) were individually grown in MRS broth at 37 °C for next day use. One tablet of commonly used medical drug (Aleve, Aspirin, Tylenol, Hydro, Lisinopril, Metformin, Metoprolol, or Glipizide) was completely dissolved into batches of 9 mL MRS broth then samples were inoculated with 1 mL of overnight grown cultures. Samples were incubated at 37 °C for 2 h and bacterial populations were determined immediately after exposure to medical drugs and after 2 h of incubation. Our result showed a decrease in bifidobacteria population by an average of 3.0 ± 0.25 log CFU/mL in the presence of tested drugs. Arthritis drug (Aleve, Aspirin, and Tylenol) showed higher killing effect on bifidobacteria compared to other tested drugs. These findings suggested that intake of common medical drugs may decrease the viability of probiotic bacteria and may reflect their contribution to human health. The intake of probiotic dietary supplements and functional foods may reduce the negative effect of medical drugs on probiotics.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013). Ageing and gut microbes: Perspectives for health maintenance and longevity. Pharmacological Research, 69(1), 11–20.
Brestoff, J. R., & Artis, D. (2013). Commensal bacteria at the interface of host metabolism and the immune system. Nature Immunology, 14(7), 676–684.
Gill, H. S. (2003). Probiotics to enhance anti-infective defences in the gastrointestinal tract. Best Practice & Research Clinical Gastroenterology, 17(5), 755–773.
Gill, H. S., Rutherfurd, K. J., Prasad, J., & Gopal, P. K. (2000). Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). British Journal of Nutrition, 83(02), 167–176.
Gill, H. S., Rutherfurd, K. J., & Cross, M. L. (2001). Dietary probiotic supplementation enhances natural killer cell activity in the elderly: An investigation of age-related immunological changes. Journal of Clinical Immunology, 21(4), 264–271.
Hayek, S. A., Shahbazi, A., Worku, M., & Ibrahim, S. A. (2013). Enzymatic activity of Lactobacillus grown in a sweet potato base medium. British Microbiology Research Journal, 4(5), 509–522.
Ibrahim, S. A., Alazzeh, A. Y., Awaisheh, S. S., Song, D., Shahbazi, A., & AbuGhazaleh, A. A. (2010). Enhancement of α-and β-galactosidase activity in Lactobacillus reuteri by different metal ions. Biological Trace Element Research, 136(1), 106–116.
Moubareck, C., Gavini, F., Vaugien, L., Butel, M. J., & Doucet-Populaire, F. (2005). Antimicrobial susceptibility of bifidobacteria. Journal of Antimicrobial Chemotherapy, 55, 38–44.
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002). Probiotics: An overview of beneficial effects. Antonie Van Leeuwenhoek, 82(1–4), 279–289.
Singh, S. (2013). An overview of NSAIDs used in anti-inflammatory and analgesic activity and prevention gastrointestinal damage. Journal of Drug Discovery and Therapeutics, 1(8), 41–51.
Song, D., Ibrahim, S., & Hayek, S. (2012). Recent application of probiotics in food and agricultural science. In E. C. Rigobelo (Ed.), Probiotics (1st ed., pp. 3–36). New York: InTech.
Tiihonen, K., Tynkkynen, S., Ouwehand, A., Ahlroos, T., & Rautonen, N. (2008). The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology. British Journal of Nutrition, 100(1), 130–137.
Woodmansey, E. J. (2007). Intestinal bacteria and ageing. Journal of Applied Microbiology, 102(5), 1178–1186.
Woodmansey, E. J., McMurdo, M. E., Macfarlane, G. T., & Macfarlane, S. (2004). Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects. Applied and Environmental Microbiology, 70(10), 6113–6122.
Acknowledgment
This work was made possible by grant number NC.X-267-5-12-170-1 from the National Institute of Food and Agriculture and its contents are solely the responsibility of the authors and do not necessarily respond to the official view of the National Institute of Food and Agriculture.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
Obanla, T.O., Hayek, S.A., Gyawali, R., Ibrahim, S.A. (2016). Interaction Between Bifidobacterium and Medical Drugs. In: Uzochukwu, G., Schimmel, K., Kabadi, V., Chang, SY., Pinder, T., Ibrahim, S. (eds) Proceedings of the 2013 National Conference on Advances in Environmental Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-19923-8_17
Download citation
DOI: https://doi.org/10.1007/978-3-319-19923-8_17
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-19922-1
Online ISBN: 978-3-319-19923-8
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)