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Treatment of Acute Migraine Attacks

  • Chapter
Pharmacological Management of Headaches

Part of the book series: Headache ((HEAD))

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Abstract

Migraine is a painful and often disabling condition which is the most frequent disabling neurological disorder, has a major impact on the patient’s quality of life and has a very high socioeconomic burden on society. The management of these patients rests on several modalities, not only on drug treatment but also on information, physiotherapy, and avoiding triggers. The treatment of acute migraine attacks has improved over the years much due to the introduction of triptans. The combination with NSAID and antiemetics will in most cases provide good relief to the subjects. This chapter provides some suggestions to the management of the acute migraine attacks in general but also in the emergency room and in children.

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References

  1. Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, Steiner T, Zwart JA (2006) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27:193–210

    Article  Google Scholar 

  2. Burch RC, Loder S, Loder E, Smitherman TA (2015) The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache 55:21–34

    Article  PubMed  Google Scholar 

  3. Linde M, Gustavsson A, Stovner LJ, Steiner TJ, Barré J, Katxarava Z, Lainez JM, Lampl C, Lantéri-Minet M, Rastenyte D, Ruiz de la Torre E, Tassorelli C, Andrée C (2012) The cost of headache disorders in Europe: the Eurolight project. Eur J Neurol 19:703.e43

    Google Scholar 

  4. Marmura MJ, Silberstein SD, Schwedt TJ (2015) The acute treatment of migraine in adults: the American Headache Society evidence assessment of migraine pharmacotherapies. Headache 55:3–20

    Article  PubMed  Google Scholar 

  5. Bendtsen L, Birk S, Kasch H, Aegidius K, Schmidt Sorensen P, Thomsen LL, Poulsen L, Rasmussen MJ, Kruuse C, Jensen R (2012) Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish headache society, 2nd edition, 2012. J Headache Pain 13(Suppl 1):S1–S29

    Article  PubMed  Google Scholar 

  6. Headache Classification of the International Headache Society (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33:627–808

    Article  Google Scholar 

  7. Ackerman S, Holland PR, Goadsby PJ (2011) Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci 12:570–584

    Article  Google Scholar 

  8. Lakhan SE, Avramut M, Tepper SJ (2013) Structural and functional neuroimaging in migraine: insights from 3 decades of research. Headache 53:46–66

    Article  PubMed  Google Scholar 

  9. Maniyar FH, Sprenger T, Monteith T, Schankin C, Goadsby PJ (2014) Brain activation in the premonitory phase of nitroglycerine-triggered migraine attacks. Brain 137:232–241

    Article  PubMed  Google Scholar 

  10. Tfelt-Hansen P, Mulder LJ, Scheldewaert RG, Schoenen J, Chazot G (1995) The effectiveness of combined oral lysine acetylsalicylate and metoclopraminde compared with oral sumatriptan for migraine. Lancet 346:923–926

    Article  CAS  PubMed  Google Scholar 

  11. Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sandon PS (2009) EFNS guideline on the drug treatment of migraine – revised report of an EFNS task force. Eur J Neurol 16:968–981

    Article  CAS  PubMed  Google Scholar 

  12. Olesen J, Diener CH, Schoenen J, Hettiarachchi J (2004) No effect of eletriptan administration during the aura phase of migraine. Eur J Neurol 11:671–677

    Article  CAS  PubMed  Google Scholar 

  13. Azzopardi TD, Brooks NA (2008) Oral metoclopramide as an adjunct to analgesics for the outpatient treatment of acute migraine. Ann Pharmacother 42:397–402

    Article  CAS  PubMed  Google Scholar 

  14. Ferrari MD, Roon KI, Lipton RB, Goadsby PJ (2001) Oral triptans (serotonin 5-HT (1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 358:1668–1675

    Article  CAS  PubMed  Google Scholar 

  15. Scholpp J, Schellenberg R, Moeckesch B, Banik N (2004) Early treatment of a migraine attack while pain is still mild increases the efficacy of sumatriptan. Cephalalgia 24:925–933

    Article  CAS  PubMed  Google Scholar 

  16. Smith TR, Sunshine A, Stark SR, Littlefield DE, Spruill SE, Alexander WJ (2005) Sumatriptan and naproxen sodium for the acute treatment of migraine. Headache 45:983–991

    Article  PubMed  Google Scholar 

  17. Schulman EA, Dermott KF (2003) Sumatriptan plus metoclopramide in triptan-nonresponsive migraineurs. Headache 43:729–733

    Article  PubMed  Google Scholar 

  18. Katsarava Z, Jensen R (2007) Medication-overuse headache: where are we now? Curr Opin Neurol 20:326–330

    Article  PubMed  Google Scholar 

  19. Diener HC, for the ASASUMAMIG Study Group (1999) Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multi-centre, parallel group study. Cephalalgia 19:581–588

    Google Scholar 

  20. Friedman BW, Greenwald P, Bania TC, Esses D, Hochberg M, Solorzano C, Corbo J, Chu J, Chew E, Cheung P, Fearon S, Paternoster J, Baccellieri A, Clark S, Bijur PE, Lipton RB, Gallagher EJ (2007) Randomized trial of IV dexamethasone for acute migraine in the emergency department. Neurology 69:2038–2044

    Article  CAS  PubMed  Google Scholar 

  21. Donaldson D, Sundermann R, Jackson R, Bastani A (2008) Intravenous dexamethasone vs placebo as adjunctive therapy to reduce the recurrence rate of acute migraine headaches: a multicenter, double-blinded, placebo-controlled randomized clinical trial. Am J Emerg Med 26:124–130

    Article  PubMed  Google Scholar 

  22. Rowe BH, Colman I, Edmonds ML, Blitz S, Walker A, Wiens S (2008) Randomized controlled trial of intravenous dexamethasone to prevent relapse in acute migraine headache. Headache 48:333–340

    Article  PubMed  Google Scholar 

  23. Evers S, Kropp P, Pothmann R, Heinen F, Ebinger F (2008) Therapie idiopathischer – Kopfschmerzen im Kindes- und Jugendalter. Nervenheilkunde 27:1127–1137

    Google Scholar 

  24. Uberall MA, Wenzel D (1999) Intranasal sumatriptan for the acute treatment of migraine in children. Neurology 52:1507–1510

    Article  Google Scholar 

  25. Winner P, Rothner AD, Saper J, Nett R, Asgharnejad M, Laurenza A, Austin R, Peykamian M (2000) A randomized, double-blind, placebo-controlled study of sumatriptan nasal spray in the treatment of acute migraine in adolescents. Pediatrics 106:989–997

    Article  CAS  PubMed  Google Scholar 

  26. Ahonen K, Hamalained M, Rantala H, Hoppu K (2004) Nasal sumatriptan is effective in treatment of migraine attacks in children: a randomized trial. Neurology 62:883–887

    Article  CAS  PubMed  Google Scholar 

  27. Evers S (1999) Drug treatment of migraine in children. A comparative review. Paediatr Drugs 1:7–18

    Article  CAS  PubMed  Google Scholar 

  28. Solomon GD, Cady RK, Klapper JA, Earl NL, Saper JR, Ramadan NM (1997) Clinical efficacy and tolerability of 2,5 mg zolmitriptan for the acute treatment of migraine. Neurology 49:1219–1225

    Article  CAS  PubMed  Google Scholar 

  29. Tepper SJ, Donnan GA, Dowson AJ, Bomhof MA, Elkind A, Meloche J, Fletcher PE, Millson DS (1999) A long-term study to maximize migraine relief with zolmitriptan. Curr Med Res Opin 15:254–271

    Article  CAS  PubMed  Google Scholar 

  30. Evers S, Rahmann A, Kraemer C, Kurlemann G, Debus O, Husstedt IW, Freze A (2006) Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen. Neurology 67:497–499

    Article  CAS  PubMed  Google Scholar 

  31. Lewis DW, Winner P, Hershey AD, Wasiewski WW, Adolescent Migraine Steering Committee (2007) Efficacy of zolmitriptan nasal spray in adolescent migraine. Pediatrics 120:390–396

    Article  PubMed  Google Scholar 

  32. Ahonen K, Hamalainen ML, Eerola M, Hoppu K (2006) A randomized trial of rizatriptan in migraine attacks in children. Neurology 67:1135–1140

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine, Institute of Clinical Sciences, Lund University, Getingevägen, Lund, 22185, Sweden

    Lars Edvinsson MD, PhD

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  1. Lars Edvinsson MD, PhD
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Correspondence to Lars Edvinsson MD, PhD .

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Editors and Affiliations

  1. Department of Neurology, Athens Naval Hospital, Athens, Greece

    Dimos D. Mitsikostas

  2. Department of Neurology, Ghent University Hospital, Ghent, Belgium

    Koen Paemeleire

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© 2016 Springer International Publishing Switzerland

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Edvinsson, L. (2016). Treatment of Acute Migraine Attacks. In: Mitsikostas, D., Paemeleire, K. (eds) Pharmacological Management of Headaches. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-19911-5_6

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  • DOI: https://doi.org/10.1007/978-3-319-19911-5_6

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19910-8

  • Online ISBN: 978-3-319-19911-5

  • eBook Packages: MedicineMedicine (R0)

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