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Neurodegenerative Disorders

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Molecular Pathology in Clinical Practice

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Abstract

Neurodegenerative disorders are characterized by progressive neuronal deterioration resulting in cognitive or mental degeneration, dementias, muscle weakness, and/or movement disorders. Some disorders, such as Alzheimer disease or Parkinson disease exhibit sporadic as well as familial forms, with familial forms generally developing at an earlier age. Others, such as Huntington disease, are always inherited. Molecular genetics has elucidated the basis for a number of neurodegenerative disorders, and molecular testing may identify familial mutations, allowing presymptomatic or prenatal testing for family members.

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Authors and Affiliations

  1. Pathology and Laboratory Medicine, Neuropathology, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce St., 6 Founders, Philadelphia, PA, 19104, USA

    Maria Martinez-Lage M.D.

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  1. Maria Martinez-Lage M.D.
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Correspondence to Maria Martinez-Lage M.D. .

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Editors and Affiliations

  1. Pathology and Laboratory Medicine, University of Vermont College of Medicine and University of Vermont Medical Center, Burlington, Vermont, USA

    Debra G.B. Leonard

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Martinez-Lage, M. (2016). Neurodegenerative Disorders. In: Leonard, D. (eds) Molecular Pathology in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-19674-9_18

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  • DOI: https://doi.org/10.1007/978-3-319-19674-9_18

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19673-2

  • Online ISBN: 978-3-319-19674-9

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