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Sepsis

  • Chapter
Surgical Intensive Care Medicine

Abstract

Sepsis represents the body’s response to an infectious insult. It is characterized by the dysregulation of the inflammatory response and of the coagulation homeostasis. Depending on the host’s predisposition and co-morbidities, as well as on the nature and intensity of the insult, sepsis may progress to severe sepsis, which may be associated with circulatory shock, multiple organ failure, and death.

Severe sepsis has become one of the most important diagnoses in intensive care units (ICUs) worldwide being the leading cause of death in hospitalized critically ill patients in the United States. An international initiative, known as “Sepsis Surviving Campaign” has been launched in order to increase its awareness and improve care. The importance of early antibiotics and early resuscitation of the cardiovascular system are now recognized as paramount. Despite the observed mortality reduction in the last years, there is a lack of new specific therapies and the incidence of severe sepsis is expected to continuously increase outgrowing the increase expected in the US population.

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Authors and Affiliations

  1. Hospital Getulio Vargas, Universidade Federal Do Piauí (UFPI), Teresina, Piaui, Brazil

    Patricia Mello MD

  2. Hospital Universitário Prof. Edgar Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil

    Dimitri Gusmao-Flores MD

  3. Department of Medicine, Cooper Medical School of Rowan University, Cooper University Hospital, Camden, NJ, USA

    R. Phillip Dellinger MD

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  1. Patricia Mello MD
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  2. Dimitri Gusmao-Flores MD
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  3. R. Phillip Dellinger MD
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Correspondence to Patricia Mello MD .

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Editors and Affiliations

  1. Department of Surgical Critical Care; Lahey Hospital and Medical Center, Division of Surgery, Burlington, Massachusetts, USA

    John M. O'Donnell

  2. Surgical Critical Care Medicine, Pr�-Card�o Hospital, Critical Care Medicine, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil

    Flávio E. Nácul

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Mello, P., Gusmao-Flores, D., Dellinger, R.P. (2016). Sepsis. In: O'Donnell, J., Nácul, F. (eds) Surgical Intensive Care Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-19668-8_28

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  • DOI: https://doi.org/10.1007/978-3-319-19668-8_28

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