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Role of Multimodality Imaging in Atherosclerotic Plaque Burden and Metabolism

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Book cover Molecular and Multimodality Imaging in Cardiovascular Disease

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Abstract

Despite significant advances in modern medicine, myocardial infarction remains the most common cause of premature death. Coronary atherosclerotic plaque rupture is thought to an initiating event in a majority of cases. Conventional imaging focused on ischaemia and stenosis has failed to identify atherosclerotic plaques with highest risk of subsequent rupture and race is now on to identify these high risk vulnerable plaques in vivo using modern imaging techniques. Here we discuss the molecular pathways leading to atherosclerotic plaque vulnerability and rupture, and the advances made in this exciting field utilizing modern imaging techniques. We focus on the utility of metabolic imaging using positron emission tomography in vascular biology and the recent exciting developments in this field. In this regard, metabolic imaging using 18F-fluoride PET-CT has shown great promise in identification of high- risk vulnerable atherosclerotic plaques, and prospective studies are now underway to investigate whether this approach can identify patients at increased risk of myocardial infarction so that ultimately these patients can be targeted with aggressive medical therapy aimed at preventing adverse events.

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Authors and Affiliations

  1. Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

    Nikhil Vilas Joshi MD, David E. Newby MD PhD & Marc R. Dweck MD PhD

  2. Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK

    Nikhil Vilas Joshi MD, David E. Newby MD PhD & Marc R. Dweck MD PhD

  3. Heart Centre, Edinburgh, UK

    Nikhil Vilas Joshi MD, David E. Newby MD PhD & Marc R. Dweck MD PhD

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  1. Nikhil Vilas Joshi MD
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  2. David E. Newby MD PhD
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  3. Marc R. Dweck MD PhD
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Correspondence to Nikhil Vilas Joshi MD .

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Editors and Affiliations

  1. Johns Hopkins University, Radiology School of Medicine, Cardiovascular Nuclear Medicine, Baltimore, Maryland, USA

    Thomas H. Schindler

  2. Johns Hopkins University, School of Medicine, Cardiology, Baltimore, Maryland, USA

    Richard T. George

  3. Radiology and Epidemiology, Johns Hopkins University, School of Medicine, Cardiology, Baltimore, Maryland, USA

    Joao A.C. Lima

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Joshi, N.V., Newby, D.E., Dweck, M.R. (2015). Role of Multimodality Imaging in Atherosclerotic Plaque Burden and Metabolism. In: Schindler, T., George, R., Lima, J. (eds) Molecular and Multimodality Imaging in Cardiovascular Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-19611-4_8

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