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Mechanisms of Bone Remodelling in Psoriatic Arthritis

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Psoriatic Arthritis and Psoriasis

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Abstract

Psoriatic arthritis (PsA) is characterized by chronic inflammatory arthritis associated with skin and/or nail changes of psoriasis. PsA manifests in the peripheral joints with both bone destruction and new bone formation while in the spine there is aberrant bone formation and vertebral fusion. The pathogenic basis for the co-existence of bone loss and paradoxical bone formation has not been explained. Several exciting discoveries in this area has improved our understanding of bone homeostatic abnormalities in PsA and these will be explored in this chapter.

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Authors and Affiliations

  1. Department of Medicine and Rheumatology, Toronto Western Hospital, University Health Network, University of Toronto, 1 East-wing-425, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada

    Nigil Haroon MD, PhD

  2. Immunology and Rheumatology Division, University of Rochester Medical Center, Rochester, NY, USA

    Christopher Ritchlin MD, MPH

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  1. Nigil Haroon MD, PhD
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  2. Christopher Ritchlin MD, MPH
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Correspondence to Nigil Haroon MD, PhD .

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Editors and Affiliations

  1. Faculty of Medicine, University of Sheffield, Sheffield, United Kingdom

    Adewale Adebajo

  2. Faculty of Medicine, University of Geneva, Geneva 14, Switzerland

    Wolf-Henning Boehncke

  3. Toronto Western Hospital, Toronto, Ontario, Canada

    Dafna D. Gladman

  4. Seattle Rheumatology Associates, Seattle, Washington, USA

    Philip J. Mease

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Haroon, N., Ritchlin, C. (2016). Mechanisms of Bone Remodelling in Psoriatic Arthritis. In: Adebajo, A., Boehncke, WH., Gladman, D., Mease, P. (eds) Psoriatic Arthritis and Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-19530-8_13

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  • DOI: https://doi.org/10.1007/978-3-319-19530-8_13

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