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Update on the Genetics of Psoriatic Arthritis

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Psoriatic Arthritis and Psoriasis

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Abstract

Psoriatic arthritis (PsA) is a common disease arising from a complex interplay between genetic, environmental and immune related factors. PsA exhibits one of the largest known recurrence risks among first degree relatives in a complex rheumatic disease. While there is substantive evidence supporting a strong genetic component of PsA, it has been difficult to elucidate genes specific to PsA pathogenesis. Investigating the genetic etiology of PsA is inherently challenging given the existence of gene-gene interactions, gene-environment interactions as well as a potential contribution of copy number variants (CNVs) and epigenetic factors. This chapter will provide an overview of the genetics basis of PsA focusing on candidate gene studies, genome-wide linkage and association-based studies, in addition to highlighting the genetics related to PsA pharmacotherapy (i.e., pharmacogenetics).

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Authors and Affiliations

  1. Faculty of Medicine, Memorial University, St. John’s, NL, Canada

    Darren D. O’Rielly PhD, FCCMG

  2. Department of Medicine, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada

    Lihi Eder MD, PhD

  3. Department of Medicine, Memorial University, St. John’s, NL, Canada

    Proton Rahman MD, MSc

Authors
  1. Darren D. O’Rielly PhD, FCCMG
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  2. Lihi Eder MD, PhD
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  3. Proton Rahman MD, MSc
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Correspondence to Proton Rahman MD, MSc .

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Editors and Affiliations

  1. Faculty of Medicine, University of Sheffield, Sheffield, United Kingdom

    Adewale Adebajo

  2. Faculty of Medicine, University of Geneva, Geneva 14, Switzerland

    Wolf-Henning Boehncke

  3. Toronto Western Hospital, Toronto, Ontario, Canada

    Dafna D. Gladman

  4. Seattle Rheumatology Associates, Seattle, Washington, USA

    Philip J. Mease

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O’Rielly, D.D., Eder, L., Rahman, P. (2016). Update on the Genetics of Psoriatic Arthritis. In: Adebajo, A., Boehncke, WH., Gladman, D., Mease, P. (eds) Psoriatic Arthritis and Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-19530-8_11

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